Mask assistance to colorimetric sniffers for detection of Covid-19 disease using exhaled breath metabolites.
Mask assistance to colorimetric sniffers for detection of Covid-19 disease using exhaled breath metabolites.
复制标题
DOI：
10.1016/j.snb.2022.132379
复制
发表时间：
2022-10-15
影响因子：
8.4
通讯作者：
Bagheri, Hasan
中科院分区：
文献类型：
--
作者：
Bordbar, Mohammad Mahdi;Samadinia, Hosein;Hajian, Ali;Sheini, Azarmidokht;Safaei, Elham;Aboonajmi, Jasem;Arduini, Fabiana;Sharghi, Hashem;Hashemi, Pegah;Khoshsafar, Hosein;Ghanei, Mostafa;Bagheri, Hasan
关键词：
根据世界卫生组织的报告，由于严重急性呼吸综合征冠状病毒2号(SARS-CoV-2)，全球已有大量人感染或死于新冠肺炎。研究人员仍在努力寻找一种快速而准确的诊断方法，以揭示病毒载量低的感染者，最重要的目标是有效的诊断管理。监测人体代谢变化被认为是评估感染者的一种有效且廉价的方法。在这里，引入了光学嗅探器来检测新冠肺炎患者(60例)、健康人(55例)和治愈人员(15例)呼出的代谢物，为研究样本之间的区分提供了独特的颜色模式。嗅探器安装在一个薄的面罩上，直接暴露在呼出的呼吸流中。挥发性化合物与传感成分之间发生的相互作用，如卟啉、改性有机染料、卟啉、无机络合物和金纳米颗粒允许颜色变化，从而被跟踪为传感器响应。对患者、健康和治愈的样本进行区分的分析准确率计算在80%-84%的范围内。传感器颜色的变化与RRT-PCR方法评估的疾病严重程度和病毒载量呈线性相关。有趣的是，肾脏、肺部和糖尿病等合并症以及吸烟者都可以通过所提出的方法进行诊断。作为一种功能强大的检测设备，呼吸嗅探仪可以取代传统的快速检测试剂盒用于医疗应用。
According to World Health Organization reports, large numbers of people around the globe have been infected or died for Covid-19 due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Researchers are still trying to find a rapid and accurate diagnostic method for revealing infected people by low viral load with the overriding goal of effective diagnostic management. Monitoring the body metabolic changes is known as an effective and inexpensive approach for the evaluation of the infected people. Here, an optical sniffer is introduced to detect exhaled breath metabolites of patients with Covid-19 (60 samples), healthy humans (55 samples), and cured people (15 samples), providing a unique color pattern for differentiation between the studied samples. The sniffer device is installed on a thin face mask, and directly exposed to the exhaled breath stream. The interactions occurring between the volatile compounds and sensing components such as porphyrazines, modified organic dyes, porphyrins, inorganic complexes, and gold nanoparticles allowing for the change of the color, thus being tracked as the sensor responses. The assay accuracy for the differentiation between patient, healthy and cured samples is calculated to be in the range of 80%—84%. The changes in the color of the sensor have a linear correlation with the disease severity and viral load evaluated by rRT-PCR method. Interestingly, comorbidities such as kidney, lung, and diabetes diseases as well as being a smoker may be diagnosed by the proposed method. As a powerful detection device, the breath sniffer can replace the conventional rapid test kits for medical applications.
登录
查看更多内容
影响因子：
8.4
作者：
Bordbar, Mohammad Mandi;Tashkhourian, Javad;Hemmateenejad, Bahram
通讯作者：
Hemmateenejad, Bahram
影响因子：
2.1
作者：
Bregy, Lukas;Nussbaumer-Ochsner, Yvonne;Zenobi, Renato
通讯作者：
Zenobi, Renato
DOI：
10.1016/j.saa.2020.119076
发表时间：
2021-02-15
影响因子：
4.4
作者：
Chaharlangi, Mahsa;Tashkhourian, Javad;Hemmateenejad, Bahram
通讯作者：
Hemmateenejad, Bahram
影响因子：
1.8
作者：
Mannu, Ranbir S.;Turpin, Phillip E.;Goodwin, Lee
通讯作者：
Goodwin, Lee
影响因子：
8.4
作者：
Khajehsharifi, Habibollah;Bordbar, Mohammad Mahdi
通讯作者：
Bordbar, Mohammad Mahdi