Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality.
Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality.
复制标题
绝经和激素替代疗法对高尿酸血症与死亡率关联的影响。
DOI：
10.1016/j.atherosclerosis.2012.10.044
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发表时间：
2013-01
期刊：
影响因子：
5.3
通讯作者：
Boyko EJ
中科院分区：
文献类型：
--
作者：
Ioannou GN;Boyko EJ
血清尿酸（SUA）水平与心血管和全因死亡率相关。目前尚不清楚这些相关性是否因性别、绝经状态和激素替代治疗（HRT）而异，以及在调整已知的心血管危险因素后是否持续存在。我们在1988-1994年招募的5856名年龄≥20岁的第三次美国国家健康和营养检查调查参与者中确定了空腹SUA水平与基于死亡证明的死亡率之间的关系，并对死亡率进行了随访，直至2006年12月（平均随访时间：13.5年;最长随访时间：18年）。考克斯比例风险回归分析用于调整人口统计学特征、心血管危险因素和其他可能与SUA水平相关的变量。在女性中，SUA水平与全因死亡率和心血管死亡率相关（SUA每增加1个单位，校正风险比[AHR]分别为1.17，95%CI 1.03-1.32和AHR 1.23（1.01-1.51））。这些相关性在绝经后妇女中持续存在，但在绝经前妇女中不存在。此外，在绝经后妇女中，仅在未接受HRT的妇女中发现SUA与全因死亡率（AHR 1.30 [1.11-1.51]）或心血管死亡率（AHR 1.61 [1.33-1.94]）之间存在显著相关性，但在接受HRT的妇女中未发现。在未校正或校正的分析中，我们没有发现SUA水平与51岁以下或51岁以上男性的全因或心血管死亡率之间的相关性。在未接受HRT的绝经后女性中，SUA水平可以独立于主要预测因素和风险因素预测心血管和全因死亡率，但在绝经前女性、接受HRT的绝经后女性或男性中则不然。
Serum uric acid (SUA) levels have been associated with cardiovascular and all-cause mortality. It remains unclear whether these associations differ by gender, menopausal status and hormone replacement therapy (HRT) and whether they persist after adjustment for known cardiovascular risk factors. We determined the associations between fasting SUA level and death certificate-based mortality among 5856 participants of the third US National Health and Nutrition Examination Survey aged ≥20 years recruited between 1988–1994 and followed for mortality until December 2006 (mean follow-up: 13.5 years; maximum follow-up: 18 years). Cox proportional hazards regression analysis was used to adjust for demographic characteristics, cardiovascular risk factors and other variables potentially associated with SUA levels. Among women, SUA level was associated with all-cause and cardiovascular mortality (adjusted hazard ratio [AHR] 1.17, 95% CI 1.03–1.32 and AHR 1.23 (1.01–1.51) respectively per unit increase in SUA. These associations persisted among postmenopausal but not premenopausal women. Furthermore, among postmenopausal women, significant associations were identified between SUA and all-cause (AHR 1.30 [1.11–1.51]) or cardiovascular (AHR 1.61 [1.33–1.94]) mortality only among women not taking HRT, but not among women on HRT. We did not identify associations between SUA levels and all-cause or cardiovascular mortality in men, either under or over 51 years of age, in unadjusted or adjusted analyses. SUA level predicts cardiovascular and all-cause mortality independently of major predictors and risk factors in postmenopausal women not taking HRT but not in premenopausal women, postmenopausal women on HRT, or men.
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影响因子：
19.6
作者：
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通讯作者：
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