Mutational robustness can facilitate adaptation.
Mutational robustness can facilitate adaptation.
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健壮性似乎是进化性的对立面。正如一些研究表明的那样，如果表型对突变具有很强的抵抗力，我们可能会认为一个群体很难适应环境的变化。然而，其他研究认为，强壮的生物体更具适应能力。对稳健性和进化性之间关系的定量理解将有助于解决这些相互矛盾的报告，并将澄清分子和实验进化、Evo-DEVO和蛋白质工程中的突出问题。使用一般的种群遗传模型，我们在这里证明了突变稳健性可以阻碍或促进适应，这取决于种群大小、突变率和适应度格局的结构。特别是，稳健种群中的中性多样性可以加速适应，前提是个体通过突变获得的表型数量少于适应度环境中的表型总数。这些结果为进化论中的一个重大歧义提供了一个定量的解决方案。
Robustness seems to be the opposite of evolvability. If phenotypes are robust against mutation, we might expect that a population will have difficulty adapting to an environmental change, as several studies have suggested. However, other studies contend that robust organisms are more adaptable. A quantitative understanding of the relationship between robustness and evolvability will help resolve these conflicting reports and will clarify outstanding problems in molecular and experimental evolution, evo-devo, and protein engineering. Using a general population-genetic model, we demonstrate here that mutational robustness can either impede or facilitate adaptation, depending on the population size, the mutation rate, and the structure of the fitness landscape. In particular, neutral diversity in a robust population can accelerate adaptation provided the number of phenotypes accessible to an individual by mutation is smaller than the total number of phenotypes in the fitness landscape. These results provide a quantitative resolution to a significant ambiguity in evolutionary theory.
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影响因子：
4.5
作者：
Cambray, Guillaume;Mazel, Didier
通讯作者：
Mazel, Didier
DOI：
10.1073/pnas.032668599
发表时间：
2002-02-05
影响因子：
11.1
作者：
Krakauer, DC;Plotkin, JB
通讯作者：
Plotkin, JB
影响因子：
2
作者：
Forster, Robert;Adami, Christoph;Wilke, Claus O.
通讯作者：
Wilke, Claus O.
影响因子：
1.6
作者：
Sumedha;Martin, Olivier C.;Wagner, Andreas
通讯作者：
Wagner, Andreas
影响因子：
4.3
作者：
Meyers, LA;Ancel, FD;Lachmann, M
通讯作者：
Lachmann, M