Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity.
Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity.
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DOI：
10.1016/j.taap.2012.04.009
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发表时间：
2012-06-15
影响因子：
3.8
通讯作者：
Keating, Aileen F.
中科院分区：
文献类型：
--
作者：
Bhattacharya, Poulomi;Keating, Aileen F.
哺乳动物的卵巢是一个异质器官，在不同的发育阶段含有卵母细胞的卵泡。最不成熟的卵泡阶段，即原始卵泡，由卵巢储备组成，数量有限，在出生时就确定了。卵巢内所有卵泡的消耗会导致生殖衰老，也就是更年期。许多化学物质会破坏卵泡，从而加速进入更年期。卵巢对化学物质暴露的反应可以决定卵巢毒性的程度。在卵巢中表达具有生物活性和解毒能力的酶，它们对卵毒性的影响部分表征为三氯乙烯，7,12-二甲基苯[a]蒽和4-乙烯基环己烯。本综述将讨论这些研究，并说明已确定为卵毒性的化学物质的知识差距。
The mammalian ovary is a heterogeneous organ, and contains oocyte-containing follicles at varying stages of development. The most immature follicular stage, the primordial follicle, comprises the ovarian reserve and is a finite number, defined at the time of birth. Depletion of all follicles within the ovary leads to reproductive senescence, known as menopause. A number of chemical classes can destroy follicles thus hastening entry into the menopausal state. The ovarian response to chemical exposure can determine the extent of ovotoxicity that occurs. Enzymes capable of bioactivating as well as detoxifying xenobiotics are expressed in the ovary and their impact on ovotoxicity have been partially characterized for trichloroethylene, 7,12-dimethylbenz[a]anthracene, and 4-vinylcyclohexene. This review will discuss those studies, as well as illustrate where knowledge gaps remain for chemicals that have also been established as ovotoxicants.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
影响因子：
10.4
作者：
Blount BC;Silva MJ;Caudill SP;Needham LL;Pirkle JL;Sampson EJ;Lucier GW;Jackson RJ;Brock JW
通讯作者：
Brock JW
影响因子：
3.8
作者：
Cummings, BS;Lash, LH
通讯作者：
Lash, LH
影响因子：
4.5
作者：
Brink, Thore C.;Demetrius, Lloyd;Lehrach, Hans;Adjaye, James
通讯作者：
Adjaye, James
影响因子：
3.3
作者：
Berger, T;Horner, CM
通讯作者：
Horner, CM