Temporal leukocyte numbers and granulocyte activation in pulsatile and rotary ventricular assist device patients.
Temporal leukocyte numbers and granulocyte activation in pulsatile and rotary ventricular assist device patients.
复制标题
脉动和旋转心室辅助装置患者的颞白细胞数量和粒细胞活化。
DOI：
10.1111/aor.12200
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发表时间：
2014
影响因子：
2.4
通讯作者：
Wagner,WilliamR
中科院分区：
文献类型：
--
作者：
Woolley,JoshuaR;Teuteberg,JeffreyJ;Bermudez,ChristianA;Bhama,JayK;Lockard,KathleenL;Kormos,RobertL;Wagner,WilliamR
个别脑室辅助装置(VAD)的设计可能会影响白细胞和影响免疫。很少有研究显示VAD患者在植入期间的白细胞和感染情况。CD11b(MAC-1)在粒细胞上的表达是炎症过程中活化、介导组织渗出和组织内活性氧释放的指标。目前尚无文献报道VAD患者外周血粒细胞上有MAC-1的表达。对1999年至2011年间植入同一中心的56名患者进行了为期120天的支持120天的跟踪观察。这些患者分别植入了心脏材料II(HMII；n= 32)、心脏器皿(HW；n= 12)或Thoratec气动VAD(n= 12)。对所有患者的白细胞谱和感染事件进行评估，并检测循环粒细胞上有MAC-1表达的亚群(HMIIn= 9；HWn= 7；PVADn= 4)。所有组的白细胞数在术后第14天(POD)出现显著峰值，同时红细胞压积显著降低。HMII患者在POD 14时粒细胞MAC-1的表达增加3.2倍，在植入期间的时间趋势与HW患者不同。此外，HW患者经历的感染事件明显较少。VAD患者所经历的白细胞分布和粒细胞激活的改变似乎是设备特有的。白细胞活性的升高可能与感染风险的增加有关，尽管在该患者组中这些现象之间的具体关系尚不清楚。
Individual ventricular assist device (VAD) design may affect leukocytes and impact immunity. Few studies have presented leukocyte and infection profiles in VAD patients over the course of the implant period. CD11b (MAC‐1) expression on granulocytes is an indicator of activation during inflammation, mediating extravasation and the release of reactive oxygen species in tissue. No reported studies have presented MAC‐1 expression on circulating granulocytes in VAD patients. Fifty‐six patients implanted at a single center with a HeartMate II (HMII;n= 32), HeartWare (HW;n= 12), or Thoratec pneumatic VAD (PVAD;n= 12) between 1999 and 2011 were followed for 120 days of support. The leukocyte profiles and infectious events of all patients were evaluated; additionally, a subset had MAC‐1 expression on circulating granulocytes was measured (HMIIn= 9; HWn= 7; PVADn= 4). All groups exhibited a significant peak in leukocyte numbers at postoperative day (POD) 14 while simultaneously experiencing a significant decrease in hematocrit. HMII patients exhibited a 3.2‐fold increase in granulocyte MAC‐1 expression at POD 14, and the temporal trend over the implant period differed from that experienced by HW patients. Further, HW patients experienced significantly fewer infection events. Alterations in leukocyte profiles and granulocyte activation experienced by VAD patients appear to be device‐specific. Elevations in leukocyte activation may be related to an increased risk for infection, although the specific relationship between these phenomena in this patient group is not known.
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影响因子：
37.8
作者：
M. Galiñanes;C. Watson;U. Trivedi;D. Chambers;C. Young;G. Venn
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DOI：
--
发表时间：
2002
期刊：
Journal of Biomedical Materials Research
影响因子：
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作者：
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DOI：
10.2741/1185
发表时间：
2003-09-01
期刊：
FRONTIERS IN BIOSCIENCE
影响因子：
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作者：
Donnenberg, VS;Donnenberg, AD
通讯作者：
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影响因子：
4.9
作者：
Jamiolkowski, Megan A.;Woolley, Joshua R.;Kameneva, Marina V.;Antaki, James F.;Wagner, William R.
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DOI：
--
发表时间：
2010
期刊：
The Journal of Heart and Lung Transplantation
影响因子：
--
作者：
S. Klotz;C. Vahlhaus;C. Riehl;C. Reitz;J. Sindermann;H. Scheld
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H. Scheld