The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells.
The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells.
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DOI：
10.3389/fonc.2020.608975
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发表时间：
2020
影响因子：
4.7
通讯作者：
Taheri M
中科院分区：
文献类型：
--
作者：
Ghafouri-Fard S;Shoorei H;Anamag FT;Taheri M
细胞周期由许多蛋白质即细胞周期蛋白依赖性激酶（CDKs）及其相关的细胞周期蛋白调节，所述细胞周期蛋白以时相特异性方式与CDKs结合并激活CDKs。此外，几种转录因子（TF）如E2F和p53和许多信号传导途径调节细胞周期进程。最近的研究强调了长链非编码RNA（lncRNA）和microRNA（miRNAs）在细胞周期调控中的作用。lncRNA和miRNAs都与转录因子相互作用，参与细胞周期转换的调节。细胞周期调节miRNA和lncRNA的失调会导致人类疾病，特别是癌症。了解lncRNA、miRNAs和TF在细胞周期调控中的作用将为设计干预细胞周期进程的抗癌疗法铺平道路。本文就lncRNA和miRNAs在细胞周期调控中的作用及其与人类恶性肿瘤的关系作一综述。
Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle progression. Recent studies have accentuated the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the regulation of cell cycle. Both lncRNAs and miRNAs interact with TFs participating in the regulation of cell cycle transition. Dysregulation of cell cycle regulatory miRNAs and lncRNAs results in human disorders particularly cancers. Understanding the role of lncRNAs, miRNAs, and TFs in the regulation of cell cycle would pave the way for design of anticancer therapies which intervene with the cell cycle progression. In the current review, we describe the role of lncRNAs and miRNAs in the regulation of cell cycle and their association with human malignancies.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
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