Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration.
Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration.
复制标题
DOI：
10.1186/s12974-021-02337-2
复制
发表时间：
2021-12-07
影响因子：
9.3
通讯作者：
Hanna AS
中科院分区：
文献类型：
--
作者：
Hellenbrand DJ;Quinn CM;Piper ZJ;Morehouse CN;Fixel JA;Hanna AS
创伤性脊髓损伤（SCI）是一种破坏性的神经系统疾病，导致运动和感觉功能的丧失。尽管对脊髓损伤的治疗方法进行了广泛的研究，但迄今为止，这些治疗方法都没有产生有意义的损伤后功能恢复。原发性损伤是由脊髓的初始损伤引起的，结果是缺血、氧化损伤、水肿和谷氨酸兴奋毒性。这一过程启动了继发性损伤级联反应，在损伤后几个小时开始，并可能持续6个月以上，导致额外的细胞死亡和脊髓损伤。脊髓损伤后的炎症是复杂的，由多种细胞和信号分子驱动。在这篇综述中，我们利用广泛的文献调查来制定啮齿动物模型脊髓损伤后局部免疫细胞和细胞因子行为的时间表。我们讨论了几种关键细胞因子的确切功能作用及其对参与继发性损伤级联的各种细胞类型的影响。此外，炎症反应在大鼠和小鼠之间的差异是突出的。由于目前的脊髓损伤治疗方案不能成功启动功能恢复或轴突再生，因此确定继发性损伤的具体机制至关重要。随着对复杂的脊髓损伤病理生理的更深入的了解，可以建立有效的治疗靶点和现实的干预时间表，以成功地减轻继发性损伤。
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a loss of motor and sensory function. Although extensive research to develop treatments for SCI has been performed, to date, none of these treatments have produced a meaningful amount of functional recovery after injury. The primary injury is caused by the initial trauma to the spinal cord and results in ischemia, oxidative damage, edema, and glutamate excitotoxicity. This process initiates a secondary injury cascade, which starts just a few hours post-injury and may continue for more than 6 months, leading to additional cell death and spinal cord damage. Inflammation after SCI is complex and driven by a diverse set of cells and signaling molecules. In this review, we utilize an extensive literature survey to develop the timeline of local immune cell and cytokine behavior after SCI in rodent models. We discuss the precise functional roles of several key cytokines and their effects on a variety of cell types involved in the secondary injury cascade. Furthermore, variations in the inflammatory response between rats and mice are highlighted. Since current SCI treatment options do not successfully initiate functional recovery or axonal regeneration, identifying the specific mechanisms attributed to secondary injury is critical. With a more thorough understanding of the complex SCI pathophysiology, effective therapeutic targets with realistic timelines for intervention may be established to successfully attenuate secondary damage.
登录
查看更多内容
影响因子：
4.8
作者：
Bethea, JR;Dietrich, WD
通讯作者：
Dietrich, WD
影响因子：
56.9
作者：
Bonni, A;Sun, Y;Greenberg, ME
通讯作者：
Greenberg, ME
影响因子：
3.4
作者：
Bartholdi, D;Schwab, ME
通讯作者：
Schwab, ME
影响因子：
4.7
作者：
Cheng, Peng;Kuang, Fang;Wang, Jian
通讯作者：
Wang, Jian
影响因子：
25
作者：
Davalos, D;Grutzendler, J;Gan, WB
通讯作者：
Gan, WB