Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy.
Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy.
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DOI：
10.1007/s10157-013-0921-6
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发表时间：
2014-10
影响因子：
2.3
通讯作者：
Tomino, Yasuhiko
中科院分区：
文献类型：
--
作者：
Suzuki, Yusuke;Matsuzaki, Keiichi;Suzuki, Hitoshi;Okazaki, Keiko;Yanagawa, Hiroyuki;Ieiri, Norio;Sato, Mitsuhiro;Sato, Toshinobu;Taguma, Yoshio;Matsuoka, Joe;Horikoshi, Satoshi;Novak, Jan;Hotta, Osamu;Tomino, Yasuhiko
免疫球蛋白A肾病(IgAN)的主要异常表现为反复发作的血尿伴或不伴蛋白尿。虽然肾活检组织的免疫组织化学分析不仅是诊断的金标准，也是评估IgAN活动性的金标准，但新的敏感和合理特异的无创性试验正在出现，以指导适用于所有阶段的IgAN的治疗策略。本研究检测了血清半乳糖缺乏性IgA1(Gd-IgA1)及其免疫复合物(IgA/Ig G-IC)水平作为疾病活动性的非侵入性标志物。我们纳入了50例经激素冲击加扁桃体切除术(TSP)后临床完全或部分缓解的IgAN患者(男性40%，中位年龄37岁)，他们的临床资料和血清可随访3~5年。横断面分析显示血尿和蛋白尿的程度与Gd-Ig A1和Ig A/Ig G-IC水平显著相关。纵向分析进一步显示，TSP前有大量血尿的44例患者中，31例血尿完全消失(A组)，其余患者未完全消失(B组)。两组TSP前Gd-Ig A1和Ig A/Ig G-IC水平差异无统计学意义，但A组Gd-Ig A1和Ig A/Ig G-IC下降百分率明显高于B组，血尿和蛋白尿判定Ig AN病情活动与血清Gd-Ig A1和Ig A/Ig G-IC水平及变化相关。这些新的非侵袭性疾病活动标记物可用于未来的活动评分系统和指导治疗方法。
The primary abnormal manifestation in immunoglobulin A nephropathy (IgAN) is recurring bouts of hematuria with or without proteinuria. Although immunohistochemical analysis of renal biopsy tissue remains the gold standard not only for diagnosis but also for evaluating the activity of IgAN, new sensitive and reasonably specific noninvasive tests are emerging to guide therapeutic strategy applicable to all stages of IgAN. The present study examined serum levels of galactose-deficient IgA1 (Gd-IgA1) and its immune complex (IgA/IgG-IC) as noninvasive markers for the disease activity. We enrolled 50 IgAN patients (male 40 %, median age 37 years) showing complete or partial clinical remission after steroid pulse therapy with tonsillectomy (TSP) whose clinical data and serum could be followed up for 3–5 years. Cross-sectional analysis revealed that the degree of hematuria and proteinuria were significantly associated with levels of Gd-IgA1 and levels of IgA/IgG-IC. Longitudinal analysis further showed that from the group of 44 patients with heavy hematuria before TSP, 31 patients showed complete disappearance of hematuria (group A), but the remaining patients did not (group B). Although the levels of Gd-IgA1 and IgA/IgG-IC in the two groups before TSP were similar, percentage decrease of Gd-IgA1 and IgA/IgG-IC levels in group A was significantly higher than in group B. Disease activity of IgAN assessed by hematuria and proteinuria correlated with serum levels and changes of Gd-IgA1 and IgA/IgG-IC. These new noninvasive disease activity markers can be useful for future activity scoring system and guiding therapeutic approaches.
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影响因子：
15.9
作者：
CZERKINSKY, C;KOOPMAN, WJ;MESTECKY, J
通讯作者：
MESTECKY, J
DOI：
10.1093/ndt/gfp273
发表时间：
2009-10
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
Goto M;Wakai K;Kawamura T;Ando M;Endoh M;Tomino Y
通讯作者：
Tomino Y
影响因子：
2.7
作者：
Maeda, A;Gohda, T;Tomino, Y
通讯作者：
Tomino, Y
影响因子：
2.3
作者：
Imai, Hirokazu;Miura, Naoto
通讯作者：
Miura, Naoto
影响因子：
13.6
作者：
Berthoux, Francois;Suzuki, Hitoshi;Novak, Jan
通讯作者：
Novak, Jan