Antimicrobial resistance of enteric pathogens in the Military Health System, 2009 - 2019.
Antimicrobial resistance of enteric pathogens in the Military Health System, 2009 - 2019.
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DOI：
10.1186/s12889-022-14466-1
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发表时间：
2022-12-08
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
急性腹泻(AD)可能会对军队的准备工作产生重大影响。医疗提供者必须了解服务人员(SMS)中肠道病原体抗菌素耐药性(AMR)的当前趋势，以便提供适当、及时的治疗选择。然而，对整个军事卫生系统(MHS)的肠道病原菌分布知之甚少。这项研究的主要目的是确定卫生部肠道病原体监测方面的差距，描述肠道病原体中AMR的流行病学，并确定美国大陆(CONUS)和美国大陆(OCONUS)以外的MHS的趋势。查询2009年1月1日至2019年12月31日期间分离和认证沙门氏菌、志贺氏菌、弯曲杆菌以及产志贺毒素的大肠杆菌(STEC)的所有标本的卫生级别7(HL7)格式的实验室数据。对抗生素敏感性试验(AST)结果进行了查询和汇总。根据样本来源、年份和药敏试验的可用性计算每种生物的描述性统计数据。在总共13,852株肠道细菌中，11,877株(86%)来自CONUS地点。从1479株志贺氏菌中检出。和6755株沙门氏菌。分别有1221株(83%)和5019株(74%)的分离株通过MHS报告了药敏结果。总体而言，只有15%的STEC和4%的弯曲杆菌。标本有AST结果。比较CONUS和OCONUS位置的AST报告，CONUS和OCONUS位置分别有1175(83%)和46(78%)志贺氏菌分离出AST，而CONUS和OCONUS位置分别有4591(76%)和428(63%)沙门氏菌报告AST。这项研究揭示了在MHS中进行的不一致的肠道病原体AST，在CONUS和OCONUS位置之间有不同的趋势。还需要开展更多的工作，以评估检测和报告方面针对病原体的差距，以制定支持部队健康的最佳监测。网上版载有补充材料，可在10.1186/s12889-022-14466-1查阅。
Acute diarrhea (AD) can have significant impacts on military troop readiness. Medical providers must understand current trends of enteropathogen antimicrobial resistance (AMR) in service members (SMs) to inform proper, timely treatment options. However, little is known of enteric pathogen profiles across the Military Health System (MHS). The primary objectives of this study were to identify gaps in enteric pathogen surveillance within the MHS, describe the epidemiology of AMR in enteric pathogens, and identify trends across the MHS both within the Continental United States (CONUS) and outside of the Continental United States (OCONUS). Health Level 7 (HL7)-formatted laboratory data were queried for all specimens where Salmonella, Shigella, and Campylobacter species, as well as Shiga toxin-producing Escherichia coli (E. coli) (STEC) were isolated and certified between 1 January 2009 - 31 December 2019. Antibiotic susceptibility testing (AST) results were queried and summarized where available. Descriptive statistics were calculated for each organism by specimen source, year, and susceptibility testing availability. Among a total of 13,852 enteric bacterial isolates, 11,877 (86%) were submitted from CONUS locations. Out of 1479 Shigella spp. and 6755 Salmonella spp. isolates, 1221 (83%) and 5019 (74%), respectively, reported any susceptibility results through the MHS. Overall, only 15% of STEC and 4% of Campylobacter spp. specimens had AST results available. Comparing AST reporting at CONUS versus OCONUS locations, AST was reported for 1175 (83%) and 46 (78%) of Shigella isolates at CONUS and OCONUS locations, respectively, and for 4591 (76%) and 428 (63%) of Salmonella isolates at CONUS and OCONUS locations, respectively. This study revealed inconsistent enteropathogen AST conducted across the MHS, with differing trends between CONUS and OCONUS locations. Additional work is needed to assess pathogen-specific gaps in testing and reporting to develop optimal surveillance that supports the health of the force. The online version contains supplementary material available at 10.1186/s12889-022-14466-1.
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DOI：
10.4269/ajtmh.2002.67.533
发表时间：
2002-11-01
影响因子：
3.3
作者：
Sanders, JW;Isenbarger, DW;Tribble, DR
通讯作者：
Tribble, DR
影响因子：
11.8
作者：
Al-Mashhadani, Manar;Hewson, Robert;Parry, Christopher M.
通讯作者：
Parry, Christopher M.
影响因子：
4.2
作者：
Mullaney, S. B.;Rao, S.;Hyatt, D. R.
通讯作者：
Hyatt, D. R.
影响因子：
4.5
作者：
Lekshmi M;Ammini P;Kumar S;Varela MF
通讯作者：
Varela MF
影响因子：
5.5
作者：
Ayukekbong JA;Ntemgwa M;Atabe AN
通讯作者：
Atabe AN