ABO blood type is associated with renal outcomes in patients with IgA nephropathy.
ABO blood type is associated with renal outcomes in patients with IgA nephropathy.
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ABO 血型与 IgA 肾病患者的肾脏结局相关
DOI：
10.18632/oncotarget.20701
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发表时间：
2017-09-26
期刊：
影响因子：
--
通讯作者：
Chen N
中科院分区：
文献类型：
--
作者：
Yang M;Xie J;Ouyang Y;Zhang X;Shi M;Li X;Wang Z;Shen P;Ren H;Zhang W;Wang W;Chen N
据报道，ABO血型抗原与炎症有关，这些抗原与免疫介导的疾病的发作和进展很大程度上涉及。肾脏活检时73m2。非B抗原组（O/A型）的患者的基线EGFR较低，收缩压（SBP），尿酸，乳酸脱氢酶，高敏感的C-反应蛋白和肿瘤坏死因子-α与B抗原组的患者相比（B/AB型）在57.46个月后（124）。 （17.7％）在非B抗原组中，B 26（7.1％） Kaplan-Meier分析表明，非B抗原组的患者中位数不含ESRD的生存时间比B抗原组的患者短[143.09±6.38 vs 159.05±4.94个月， p = 0.002）在按年龄进行完全调整后，性别，SBP，EGFR，血液尿素氮，尿酸，尿酸，甘油三酸酯，血红蛋白，血清C3，尿液蛋白，牛津分类，总的来说，我们的研究表明，ABO的血型可能会增加了IGAN的危险因素。 atory地位。
ABO blood group antigens have been reported to be associated with inflammation and infections which have been largely implicated in the onset and progression of immune-mediated diseases. This study aimed to evaluate the association between ABO blood group and progression of IgA nephropathy (IgAN). We retrospectively enrolled 919 biopsy-proven IgAN patients with a minimum follow-up of 1 year and eGFR≥15ml/min/1.73m2 at the time of renal biopsy. Patients in non-B antigen group (type O/A) had lower baseline eGFR, higher systolic blood pressure (SBP), uric acid, lactate dehydrogenase, high-sensitive C-reactive protein and tumor necrosis factor-α compared to patients in B antigen group(type B/AB). After a median follow-up of 57.46 months, 124(13.5%) patients progressed to end-stage renal disease (ESRD) including 98(17.7%) in non-B antigen group and 26(7.1%) in B antigen group. Kaplan-Meier analysis showed the median ESRD-free survival time of patients in non-B antigen group was significantly shorter than patients in B antigen group [143.09±6.38 vs 159.05±4.94months, p < 0.001]. Furthermore, non-B antigen blood group was associated with an independently increased risk of ESRD (HR=2.21, 95%CI 1.35-3.62, p = 0.002) after fully adjusted by age, sex, SBP, eGFR, blood urea nitrogen, hypoalbuminemia, uric acid, triglycerides, hemoglobin, serum C3, urine protein, Oxford classification and glucocorticoid treatment. In conclusion, our study suggests that ABO blood type is a new risk factor for IgAN progression. IgAN patients with blood type O or A have an independent increased risk for renal function deterioration which might be explained by an increased level of inflammatory status.
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