Clinical, hematologic, and immunologic cross-sectional evaluation of individuals exposed to human immunodeficiency virus type-2 (HIV-2).
Clinical, hematologic, and immunologic cross-sectional evaluation of individuals exposed to human immunodeficiency virus type-2 (HIV-2).
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对暴露于人类免疫缺陷病毒 2 型 (HIV-2) 的个体进行临床、血液学和免疫学横断面评估。
DOI：
10.1089/aid.1988.4.137
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发表时间：
1988
影响因子：
1.5
通讯作者：
Chou,MJ
中科院分区：
文献类型：
--
作者：
Marlink,RG;Ricard,D;M'Boup,S;Kanki,PJ;Romet-Lemonne,JL;N'Doye,I;Diop,K;Simpson,MA;Greco,F;Chou,MJ
我们研究了来自塞内加尔达喀尔的健康妓女的临床状况和某些血液学和免疫学参数，这些妓女对人类免疫缺陷病毒2型（HIV-2）抗体呈血清阳性。不存在与人类免疫缺陷病毒1型（HIV-1）感染相似的全身性淋巴结病和临床体征或症状。与血清阴性妓女和小手术对照患者进行比较，观察到T8淋巴细胞（p= 0.03）、IgG（p= 0.0001）和β2-微球蛋白（p= 0.03）显著升高。血清反应阳性妓女的平均T4淋巴细胞计数低于血清反应阴性妓女（757 vs. 1179，p= 0.15），但这种差异无统计学意义，似乎与年龄有关。血清阴性和血清阳性妓女在淋巴细胞刺激研究中对某些有丝分裂原没有显着差异。两个人群中都不存在高于背景的抗淋巴细胞抗体。我们得出的结论是，HIV-2是一种性传播媒介，会产生与持续病毒感染一致的免疫学改变。迄今为止，对艾滋病毒2型血清反应阳性的妓女进行的研究并未显示出与艾滋病毒1型感染者一样的免疫抑制临床症状。HIV-2的致病潜力似乎不同于HIV-1，后者是艾滋病大流行的病原体。
We studied the clinical status and certain hematologic and immunologic parameters in healthy prostitutes from Dakar, Senegal who were seropositive for antibodies to human immunodeficiency virus type-2 (HIV-2). Generalized lymphadenopathy and clinical signs or symptoms similar to those which are seen with human immunodeficiency virus type-1 (HIV-1) infection were not present. Comparison to seronegative prostitutes and minor surgery control patients were made and significant elevations were seen in T8 lymphocytes (p=.03), IgG (p=.0001), and β2-microglobulin (p=.03). The mean T4 lymphocyte count in seropositive prostitutes was lower than in seronegative prostitutes (757 vs. 1179,p=.15), but this difference was not statistically significant and appeared to be correlated with age. No significant differences were noted between the seronegative and seropositive prostitutes in lymphocyte stimulation studies to certain mitogens. Antilymphocyte antibodies above background were not present in either population.We conclude that HIV-2 is a sexually transmitted agent that produces immunologic alterations consistent with a persistent viral infection. HIV-2 seropositive prostitutes studied to date do not show clinical signs of immune suppression, as has been described with HIV-1 infection. The pathogenic potential of HIV-2 appears to differ from that of HIV-1, the etiologic agent of the AIDS pandemic.
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艾滋病中异常的血清学特征
DOI：
--
发表时间：
1986
期刊：
The Lancet
影响因子：
--
作者：
R. Marlink;J. Allan;M. Essex
通讯作者：
M. Essex
科特迪瓦人类 T 淋巴细胞逆转录病毒 III 型 (HIV) 和 IV 型的流行情况
DOI：
--
发表时间：
1987
期刊：
The Lancet
影响因子：
--
作者：
F. Denis;G. Gershy;M. Lhuillier;G. Léonard;A. Goudeau;M. Essex;F. Barin;J. Rey;M. Mounier;A. Sangaré;S. M'boup;P. Kanki
通讯作者：
P. Kanki
正常血液学值：中性粒细胞计数的性别差异。
影响因子：
--
作者：
B. Bain;J. England
通讯作者：
J. England
影响因子：
56.9
作者：
QUINN, TC;MANN, JM;PIOT, P
通讯作者：
PIOT, P
妓女：感染人类 T 细胞淋巴细胞病毒 III 型的高危人群
DOI：
10.1016/s0140-6736(85)90462-3
发表时间：
1985
期刊：
The Lancet
影响因子：
--
作者：
P. Perre;M. Carael;M. Robert;N. Clumeck;E. Nzabihimana;P. Mol;P. Freyens;R. Gallo;J. Butzler;J. Kanyamupira
通讯作者：
J. Kanyamupira