Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study.
Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study.
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DOI：
10.1016/j.pscychresns.2011.05.005
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发表时间：
2011-11-30
影响因子：
2.3
通讯作者：
Lohr, James
中科院分区：
文献类型：
--
作者：
Brown, Gregory G.;Lee, Jun-Seok;Strigo, Irina A.;Caligiuri, Michael P.;Meloy, M. J.;Lohr, James
对照试验为元分析产生的假设提供关键检验。最近的两项荟萃分析报道，精神分裂症和双相I型患者的杏仁核、海马体或前扣带灰质体积不同。本磁共振成像研究通过基于横截面体素的形态测量（VBM）设计对17名慢性精神分裂症患者和15名慢性双相情感障碍患者以及21名符合年龄、性别和病程的健康受试者进行了验证。精神分裂症组和双相情感障碍组的全脑灰质体积均小于健康对照组。区域体素比较显示，两组患者的额叶和颞叶区域的灰质体积最小。兴趣区分析发现，精神分裂症受试者和健康受试者在杏仁核和海马体上存在中等到较大的差异。两组间前扣带无明显差异。当直接比较精神分裂症组和双相情感障碍组时，精神分裂症组在涉及右侧海马、壳核和杏仁核的右侧皮质下区域显示出较小的GM体积。海马体和杏仁核的发现证实了最近荟萃分析的预测。这些结构异常可能是区分这两种功能性精神障碍的重要因素。
Controlled trials provide critical tests of hypotheses generated by meta-analyses. Two recent meta-analyses have reported that gray matter volumes of schizophrenia and bipolar I patients differ in the amygdala, hippocampus, or perigenual anterior cingulate. The present magnetic resonance imaging study tested these hypotheses in a cross-sectional voxel-based morphometry (VBM) design of 17 chronic schizophrenia and 15 chronic bipolar patients and 21 healthy subjects matched for age, gender and duration of illness. Whole brain gray matter volume of both the schizophrenia and bipolar groups was smaller than among healthy control subjects. Regional voxel-wise comparisons showed that gray matter volume was smallest within frontal and temporal regions of both patient groups. Region of interest analyses found moderately large to large differences between schizophrenia and healthy subjects in the amygdala and hippocampus. There were no group differences in the perigenual anterior cingulate. When schizophrenia and bipolar groups were directly compared, the schizophrenia group showed smaller GM volumes in right subcortical regions involving the right hippocampus, putamen, and amygdala. The hippocampal and amygdala findings confirm predictions derived from recent meta-analyses. These structural abnormalities may be important factors in the differential manifestations of these two functional psychotic disorders.
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影响因子：
4.5
作者：
Bose, Subrata K.;Mackinnon, Toby;Grasby, Paul M.
通讯作者：
Grasby, Paul M.
影响因子：
10.6
作者：
Blumberg, HP;Krystal, JH;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
--
作者：
Ettinger, Ulrich;Picchioni, Marco;Murray, Robin M.
通讯作者：
Murray, Robin M.
DOI：
10.1073/pnas.93.18.9985
发表时间：
1996-09-03
影响因子：
11.1
作者：
Andreasen, NC;OLeary, DS;Hichwa, RD
通讯作者：
Hichwa, RD
影响因子：
4.5
作者：
Ellison-Wright, Ian;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.