Mapping anterior temporal lobe language areas with fMRI: a multicenter normative study.
Mapping anterior temporal lobe language areas with fMRI: a multicenter normative study.
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DOI：
10.1016/j.neuroimage.2010.09.048
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发表时间：
2011-01-15
期刊：
影响因子：
5.7
通讯作者：
Weaver KE
中科院分区：
文献类型：
--
作者：
Binder JR;Gross WL;Allendorfer JB;Bonilha L;Chapin J;Edwards JC;Grabowski TJ;Langfitt JT;Loring DW;Lowe MJ;Koenig K;Morgan PS;Ojemann JG;Rorden C;Szaflarski JP;Tivarus ME;Weaver KE
切除前颞叶（ATL）是治疗顽固性颞叶癫痫的有效手术方法，但存在语言和文字记忆缺陷的风险。手术前定位ATL的功能区可能有助于降低这些风险，但目前广泛使用的功能磁共振成像协议在该区域产生很少的激活。最近的证据表明，在语义整合的ATL的作用的基础上，我们设计了一个功能磁共振成像协议比较理解的简短的叙述（故事任务）与语义浅控制任务，涉及串行算术（数学任务）。故事>数学对比在18名健康参与者的初始队列中引发了整个ATL，外侧颞叶和内侧颞叶双侧的强烈激活。然后在其他6个成像中心使用相同的方法实施任务方案。在这些中心扫描的第二组参与者的数据与第一组的结果非常相似。Story-Math方案为激活ATL中的手术感兴趣区域提供了可靠的方法。双侧激活支持先前的主张，概念加工涉及两个颞叶。与语言侧化措施相结合，可靠的ATL激活地图可能有助于预测ATL手术的认知结果，但这种方法的有效性需要建立在一个前瞻性的手术系列。
Removal of the anterior temporal lobe (ATL) is an effective surgical treatment for intractable temporal lobe epilepsy but carries a risk of language and verbal memory deficits. Preoperative localization of functional zones in the ATL might help reduce these risks, yet fMRI protocols in current widespread use produce very little activation in this region. Based on recent evidence suggesting a role for the ATL in semantic integration, we designed an fMRI protocol comparing comprehension of brief narratives (Story task) with a semantically shallow control task involving serial arithmetic (Math task). The Story > Math contrast elicited strong activation throughout the ATL, lateral temporal lobe, and medial temporal lobe bilaterally in an initial cohort of 18 healthy participants. The task protocol was then implemented at 6 other imaging centers using identical methods. Data from a second cohort of participants scanned at these centers closely replicated the results from the initial cohort. The Story-Math protocol provides a reliable method for activation of surgical regions of interest in the ATL. The bilateral activation supports previous claims that conceptual processing involves both temporal lobes. Used in combination with language lateralization measures, reliable ATL activation maps may be useful for predicting cognitive outcome in ATL surgery, though the validity of this approach needs to be established in a prospective surgical series.
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