The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis.
The Placental Epigenome as a Molecular Link Between Prenatal Exposures and Fetal Health Outcomes Through the DOHaD Hypothesis.
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通过DOHD假说，胎盘表观基因组作为产前暴露和胎儿健康结局之间的分子联系。
DOI：
10.1007/s40572-022-00354-8
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发表时间：
2022-09
影响因子：
7.9
通讯作者：
Paquette, Alison G.
中科院分区：
文献类型：
--
作者：
Lapehn, Samantha;Paquette, Alison G.
健康和疾病的发育起源（DOHaD）假说认为，围产期环境可以影响胎儿和以后的生活健康。在DOHaD的背景下，胎盘是评估产前暴露的独特位置，因为它是一个重要的短暂胎儿器官，负责管理母亲和胎儿之间的氧气、营养物质、废物和内分泌信号的运输。本文旨在总结最近使用表观基因组学评估人类胎盘中DOHaD假设的研究，包括mRNA、lncRNA和microRNA的DNA甲基化和转录组学研究。在2016年至2021年期间，28篇文章评估了产前暴露与胎盘表观基因组学之间的关联，涵盖广泛的暴露类别，包括母亲吸烟，心理社会压力，化学品，空气污染和金属。这些研究中有16项通过中介分析、暴露与结果之间的共同关联的识别或网络分析将暴露与健康结果（如出生体重、胎儿生长或婴儿神经行为）联系起来。婴儿和儿童健康的这些方面作为未来研究的基础，旨在利用胎盘表观遗传学来了解产前环境和围产期并发症（如早产或胎儿生长受限）或以后的儿童健康之间的关系。胎盘DNA甲基化和RNA表达与许多产前暴露有关，如PM2.5空气污染，金属和母亲吸烟，以及婴儿和儿童健康结果，包括胎儿生长和出生体重。胎盘表观基因组学提供了一个独特的机会，以扩大DOHaD的前提，特别是如果研究应用新的方法，如多组学分析，非编码RNA的测序，混合物分析，并评估幼儿期后的健康结果。
The developmental origins of health and disease (DOHaD) hypothesis posits that the perinatal environment can impact fetal and later life health. The placenta is uniquely situated to assess prenatal exposures in the context of DOHaD because it is an essential ephemeral fetal organ that manages the transport of oxygen, nutrients, waste, and endocrine signals between the mother and fetus. The purpose of this review is to summarize recent studies that evaluated the DOHaD hypothesis in human placentas using epigenomics, including DNA methylation and transcriptomic studies of mRNA, lncRNA, and microRNAs. Between 2016 and 2021, 28 articles evaluated associations between prenatal exposures and placental epigenomics across broad exposure categories including maternal smoking, psychosocial stressors, chemicals, air pollution, and metals. Sixteen of these studies connected exposures to health outcome such as birth weight, fetal growth, or infant neurobehavior through mediation analysis, identification of shared associations between exposure and outcome, or network analysis. These aspects of infant and childhood health serve as a foundation for future studies that aim to use placental epigenetics to understand relationships between the prenatal environment and perinatal complications (such as preterm birth or fetal growth restriction) or later life childhood health. Placental DNA methylation and RNA expression have been linked to numerous prenatal exposures, such as PM2.5 air pollution, metals, and maternal smoking, as well as infant and childhood health outcomes, including fetal growth and birth weight. Placental epigenomics provides a unique opportunity to expand the DOHaD premise, particularly if research applies novel methodologies such as multi-omics analysis, sequencing of non-coding RNAs, mixtures analysis, and assessment of health outcomes beyond early childhood.
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