Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
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DOI：
10.1016/j.envint.2018.02.014
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发表时间：
2018-05
影响因子：
11.8
通讯作者：
Nohara K
中科院分区：
文献类型：
--
作者：
Barouki R;Melén E;Herceg Z;Beckers J;Chen J;Karagas M;Puga A;Xia Y;Chadwick L;Yan W;Audouze K;Slama R;Heindel J;Grandjean P;Kawamoto T;Nohara K
各种实验和流行病学研究支持健康和疾病的发育起源（DOHaD）概念。然而，早期暴露的中长期影响的实际机制仍不清楚。表观遗传学改变，如DNA甲基化，组蛋白修饰和某些RNA的表达的变化已被认为是环境压力对健康的长期影响的可能介质。本报告记录了在日本举行的上一次产前规划和毒性会议期间进行的讨论和辩论的结论。它的第一个目标是提出一些标准，这些标准对于支持表观遗传学在DOHaD和环境压力影响的代际传递中的主要贡献至关重要。主要的标准是对压力源的充分定性、实际接触窗口、目标组织和功能、表观遗传变化的特异性以及这些变化与健康结果之间联系的生物学可解释性。第二个目的是讨论一些压力源，如吸烟，空气污染和内分泌干扰物的长期影响，以确定参数支持参与的表观遗传机制。根据制定的标准，缺失的证据和建议，为未来的研究将被确定。第三个目的是批判性地分析证据支持参与的表观遗传机制的代际和跨代的环境暴露的影响，特别是讨论胎盘和精子的作用。虽然这篇文章不是一个系统的综述，并不意味着是详尽的，但它批判性地评估了表观遗传学在环境暴露的长期影响中的贡献，并为未来的研究提供了见解。
A variety of experimental and epidemiological studies lend support to the Developmental Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for mid- and long-term effects of early-life exposures remain unclear. Epigenetic alterations such as changes in DNA methylation, histone modifications and the expression of certain RNAs have been suggested as possible mediators of long-term health effects of environmental stressors. This report captures discussions and conclusions debated during the last Prenatal Programming and Toxicity meeting held in Japan. Its first aim is to propose a number of criteria that are critical to support the primary contribution of epigenetics in DOHaD and intergenerational transmission of environmental stressors effects. The main criteria are the full characterization of the stressors, the actual window of exposure, the target tissue and function, the specificity of the epigenetic changes and the biological plausibility of the linkage between those changes and health outcomes. The second aim is to discuss long-term effects of a number of stressors such as smoking, air pollution and endocrine disruptors in order to identify the arguments supporting the involvement of an epigenetic mechanism. Based on the developed criteria, missing evidence and suggestions for future research will be identified. The third aim is to critically analyze the evidence supporting the involvement of epigenetic mechanisms in intergenerational and transgenerational effects of environmental exposure and to particularly discuss the role of placenta and sperm. While the article is not a systematic review and is not meant to be exhaustive, it critically assesses the contribution of epigenetics in the long-term effects of environmental exposures as well as provides insight for future research.
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DOI：
10.1038/nrendo.2016.186
发表时间：
2017-03
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
Braun JM
通讯作者：
Braun JM
影响因子：
0.5
作者：
Bruner-Tran, Kaylon L;Resuehr, David;Ding, Tianbing;Lucas, John A;Osteen, Kevin G
通讯作者：
Osteen, Kevin G
影响因子：
3.6
作者：
Baccarelli A;Bollati V
通讯作者：
Bollati V
DOI：
10.1186/1476-069x-11-42
发表时间：
2012-06-27
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Barouki R;Gluckman PD;Grandjean P;Hanson M;Heindel JJ
通讯作者：
Heindel JJ
影响因子：
3.7
作者：
Dhimolea E;Wadia PR;Murray TJ;Settles ML;Treitman JD;Sonnenschein C;Shioda T;Soto AM
通讯作者：
Soto AM