Rapid synaptic and gamma rhythm signature of mouse critical period plasticity.
Rapid synaptic and gamma rhythm signature of mouse critical period plasticity.
复制标题
DOI：
10.1073/pnas.2123182120
复制
发表时间：
2023-01-10
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
关键时期是大脑网络快速可塑性和重塑的发展窗口，其轨迹尚未完全了解。在这里，我们将小鼠视觉皮层感觉失衡引起的瞬时 γ 振荡识别为快速 TC 可塑性的标志，只有当这些窗口打开时。使用计算模型，我们解释了这些瞬态 γ 节律的起源及其在重新连接 TC 网络以启动临界期到临界期过渡中的作用。这些发现提供了开放关键期状态的强大非侵入性生物标志物，可用于探测大脑发育的脱轨轨迹。早期生活经历持久地塑造了丘脑皮质 (TC) 轴突和感觉处理。在这里，我们确定了启动关键期可塑性的第一个突触目标，这是由皮质振荡改变所预示的。单眼剥夺（MD）会急性诱导脑电图γ功率（约40赫兹）短暂（<3小时）峰值，特别是在视觉皮层内，但仅在关键期开放时（幼年小鼠或成年小鼠在黑暗饲养、Lynx1缺失或地西泮挽救的GAD65缺陷后）。在 MD 数小时内，在保留视觉通路的 TC 切片中，观察到表达小清蛋白 (PV) 的抑制性中间神经元（但不包括附近的锥体细胞）上的 TC 输入快速丢失——一旦关键期开启，同样如此。响应 MD 的新兴 γ 节律的计算 TC 模型描绘了关键期开始时带有间隙连接的 PV 细胞网络中的皮质神经元间 γ (ING) 节律。 ING 节律有效地将丘脑输入与皮质尖峰分离，通过标准的尖峰时间依赖性可塑性规则，导致先前强大的 TC 到 PV 连接迅速丧失。因此，以前沉默的 TC 到 PV 连接可以在较慢的时间尺度上加强，捕获逐渐增加的 γ 频率并随着时间的推移最终淡出。因此，ING 使皮层动力学能够从由最强 TC 输入主导的皮层动态转变为在 MD 后感知群体 TC 输入统计数据的皮层动态。总而言之，我们的研究结果揭示了关键期可塑性背后的初始突触事件，并表明伴随短暂感觉扰动的短暂 ING 可以作为 TC 网络状态的可靠读数，用于探测发育轨迹。
Critical periods are developmental windows of rapid plasticity and remodeling of brain networks, whose trajectories are not yet fully understood. Here, we identify transient γ-oscillations induced by sensory imbalance in the mouse visual cortex as a signature of rapid TC plasticity, only when these windows are open. Using computational modeling, we explain the origin of these transient γ-rhythms and their role in rewiring TC networks to initiate the precritical to critical period transition. These findings offer a robust noninvasive biomarker of open critical period state with which to probe derailed trajectories of brain development. Early-life experience enduringly sculpts thalamocortical (TC) axons and sensory processing. Here, we identify the very first synaptic targets that initiate critical period plasticity, heralded by altered cortical oscillations. Monocular deprivation (MD) acutely induced a transient (<3 h) peak in EEG γ-power (~40 Hz) specifically within the visual cortex, but only when the critical period was open (juvenile mice or adults after dark-rearing, Lynx1-deletion, or diazepam-rescued GAD65-deficiency). Rapid TC input loss onto parvalbumin-expressing (PV) inhibitory interneurons (but not onto nearby pyramidal cells) was observed within hours of MD in a TC slice preserving the visual pathway – again once critical periods opened. Computational TC modeling of the emergent γ-rhythm in response to MD delineated a cortical interneuronal gamma (ING) rhythm in networks of PV-cells bearing gap junctions at the start of the critical period. The ING rhythm effectively dissociated thalamic input from cortical spiking, leading to rapid loss of previously strong TC-to-PV connections through standard spike-timing-dependent plasticity rules. As a consequence, previously silent TC-to-PV connections could strengthen on a slower timescale, capturing the gradually increasing γ-frequency and eventual fade-out over time. Thus, ING enables cortical dynamics to transition from being dominated by the strongest TC input to one that senses the statistics of population TC input after MD. Taken together, our findings reveal the initial synaptic events underlying critical period plasticity and suggest that the fleeting ING accompanying a brief sensory perturbation may serve as a robust readout of TC network state with which to probe developmental trajectories.
登录
查看更多内容
影响因子：
25
作者：
Cruikshank, Scott J.;Lewis, Timothy J.;Connors, Barry W.
通讯作者：
Connors, Barry W.
影响因子：
4.9
作者：
Gogolla, Nadine;LeBlanc, Jocelyn J.;Quast, Kathleen B.;Sudhof, Thomas C.;Fagiolini, Michela;Hensch, Takao K.
通讯作者：
Hensch, Takao K.
丘脑皮质突触的快速结构重塑使小鼠初级视觉皮层的经验依赖性功能可塑性。
DOI：
10.1523/jneurosci.1248-10.2010
发表时间：
2010-07-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Coleman JE;Nahmani M;Gavornik JP;Haslinger R;Heynen AJ;Erisir A;Bear MF
通讯作者：
Bear MF
影响因子：
25
作者：
Chang, Michael C.;Park, Joo Min;Pelkey, Kenneth A.;Grabenstatter, Heidi L.;Xu, Desheng;Linden, David J.;Sutula, Thomas P.;McBain, Chris J.;Worley, Paul F.
通讯作者：
Worley, Paul F.
DOI：
10.1073/pnas.1208093110
发表时间：
2013-02-19
影响因子：
11.1
作者：
Aton, Sara J.;Broussard, Christopher;Frank, Marcos G.
通讯作者：
Frank, Marcos G.