Human cochlear diffusion from the cerebrospinal fluid space with gadolinium contrast.

Human cochlear diffusion from the cerebrospinal fluid space with gadolinium contrast.
复制标题

与钆对比的人耳蜗从脑脊液空间的扩散。

DOI:
10.1016/j.ymthe.2023.08.001
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发表时间:
2023
期刊:
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子:
--
通讯作者:
Nelson,RickF
Nelson,RickF
中科院分区:
--
文献类型:
--
作者:
Totten,DouglasJ;Booth,KevinTA;Mosier,KristineM;Cumpston,EvanC;Whitted,Cody;Okechuku,Vanessa;Koontz,NicholasA;Nelson,RickF

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脑池造影在临床上用于诊断和定位颅底处的CSF泄漏。颞骨的自发性CSF泄漏在没有激发事件的情况下发生,并且与颅骨变薄和颅底的骨缺损相关,CSF通过这些骨缺损泄漏到中耳或乳突中。1在具有挑战性的诊断病例中,我们的团队使用MRI脑池造影,包括在荧光镜下腰椎穿刺,将500 μL钆对比螯合物(Gd-BOPTA,MultiHance,Brenda,Milan,意大利)注入鞘内(CSF)空间,然后在同一天以3 T场强进行连续MR成像。2出乎意料的是,我们观察到钆造影剂快速和进行性扩散到人类耳蜗和前庭(图1)。我们评估了2019年至2021年疑似自发性CSF泄漏的15例连续患者的MRI脑池图(表S1和S2)。8名患者(53%)在初次或延迟成像时发现CSF泄漏,而7名患者没有。在8例确诊为脑脊液漏的患者中,5例为自发性,2例为创伤性,1例发生在前庭神经鞘瘤经皮切除术后。在初始成像中,在100%的患者中观察到耳蜗的钆转导(图1)。前庭摄取,无论是在初始或延迟扫描,观察
Cisternograms are employed clinically to diagnose and localize CSF leaks at the skull base. Spontaneous CSF leaks of the temporal bone occur without an inciting event and are associated with calvarial thinning and bony defects of the skull base through which CSF leaks into the middle ear or mastoid. 1 In challenging diagnostic cases, our team utilizes MRI cisternograms, which involve fluoroscopic lumbar puncture with injection of 500 μL of gadolinium contrast chelate (Gd-BOPTA, MultiHance, Bracco, Milan, Italy) into the intrathecal (CSF) space followed by same-day serial MR imaging performed at 3T field strength. 2 Unexpectedly, we observed rapid and progressive diffusion of gadolinium contrast into the human cochleae and vestibule (Figure 1).We assessed MRI cisternograms from 15 consecutive patients suspected of having a spontaneous CSF leak from 2019 to 2021 (Tables S1 and S2). Eight patients (53%) were found to have a CSF leak on initial or delayed imaging, while seven patients did not. Among the eight patients with a confirmed CSF leak, five were spontaneous, two were traumatic, and one occurred postoperatively following a translabyrinthine resection of a vestibular schwannoma. Gadolinium transduction of the cochlea was observed in 100% of the patients on initial imaging (Figure 1). Vestibular uptake, upon either initial or delayed scan, was observed
昆虫血淋巴:飞蝗体液和细胞因子之间的合作
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发表时间: 1989
期刊:
影响因子: --
作者:
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发表时间: 1986
期刊: Genetics
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期刊: Genetics
影响因子: 3.3
作者:
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通讯作者: Wright,TR
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期刊: Pigment cell research
影响因子: --
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通讯作者: J. Lozano
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影响因子: 2.2
作者:
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通讯作者: HAYES, RO