Compartmental analysis of three-dimensional choroidal vascularity and thickness of myopic eyes in young adults using SS-OCTA.
Compartmental analysis of three-dimensional choroidal vascularity and thickness of myopic eyes in young adults using SS-OCTA.
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DOI：
10.3389/fphys.2022.916323
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发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
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目的：目的：应用扫频光源光学相干断层扫描血管造影（SS-OCTA）技术，研究青年近视患者三维（3D）脉络膜厚度（ChT）、脉络膜血管容积（CVV）和脉络膜血管指数（CVI）的变化，并比较黄斑和视盘不同象限的这些指标的差异。 方法：本横断面研究共使用了135名参与者的248只眼样本。每位参与者都接受了详细的病史和眼科检查。根据眼轴长度将患者分为正视组、轻度近视组、中度近视组和高度近视组。以中心凹和视盘为中心进行6 mm × 6 mm（1，024 × 1024 B扫描）SS-OCTA扫描。基于内置的深度学习算法测量3D ChT、CVV和CVI。分析不同地区、不同近视组ChT、CVV、CVI的差异。 结果如下：HM组（1.930 ± 0.865）的总体CVV显著低于EM组（3.486 ± 0.992）、MIM组（3.238 ± 1.033）和HM组（2.589 ± 1.083）（p < 0.001）。HM组的总体CVI（0.258 ± 0.061）也低于EM（0.320 ± 0.055）、MIM（0.320 ± 0.051）和MOM（0.286 ± 0.066）组（p < 0.001）。HM组ChT（242.753 ± 65.641）较EM组（377.532 ± 80.593）、MIM组（348.367 ± 78.191）、REM组（300.197 ± 87.175）薄（p < 0.001）。房室模型分析显示黄斑鼻侧象限和视盘颞下象限的ChT、CVV和CVI明显低于其他象限（p < 0.05）。相关分析发现ChT、CVV和CVI与AL和球镜当量呈负相关。 结论：3D ChT、CVV、CVI随近视程度的增加而逐渐降低。黄斑鼻侧、视盘颞侧和下侧的变化更为显著。这些发现证明了3D脉络膜变化，并强调视乳头-黄斑束是近视发展的敏感区域。
Purpose: We aimed to investigate the change of three-dimensional (3D) choroidal thickness (ChT), choroidal vessel volume (CVV), and choroidal vessel index (CVI) in young myopic adults using swept-source optical coherence tomography angiography (SS-OCTA) and compare the difference of these indicators in different quadrants of the macula and optic disc. Methods: A total of 248 eye samples from 135 participants were used in this cross-sectional study. Each participant underwent detailed history taking and ocular examinations. Based on axial length (AL), patients were divided into the emmetropia (EM) group, mild-myopia (MIM) group, moderate-myopia (MOM) group, and high-myopia (HM) group. 6 mm × 6 mm (1,024 × 1024 B-scans) SS-OCTA scans were performed centered on the fovea and optic disc. 3D ChT, CVV, and CVI were measured based on a built-in deep learning algorithm. Differences in ChT, CVV, and CVI were analyzed in different regions and different myopic groups. Results: Significant reduction in the global CVV were found in the HM group (1.930 ± 0.865) in comparison with the EM (3.486 ± 0.992), MIM (3.238 ± 1.033), and MOM (2.589 ± 1.083) groups (p < 0.001). The global CVI was also lower in the HM group (0.258 ± 0.061) than in the EM (0.320 ± 0.055), MIM (0.320 ± 0.051), and MOM (0.286 ± 0.066) groups (p < 0.001). The ChT was thinner in eyes with HM (242.753 ± 65.641) than in eyes with EM (377.532 ± 80.593), MIM (348.367 ± 78.191), or MOM (300.197 ± 87.175) (p < 0.001). Compartmental analysis revealed that ChT, CVV, and CVI in the nasal quadrant of the macula and temporal and inferior quadrants of the optic disc were much lower than those in other quadrants (p < 0.05). Correlation analyses found that ChT, CVV, and CVI were negatively correlated with AL and spherical equivalence. Conclusion: 3D ChT, CVV, and CVI gradually decreased as the degree of myopia increased. The changes were more dramatic on the nasal side of the macula and the temporal and inferior sides of the optic disc. These findings demonstrated the 3D choroidal change and highlighted the papillo-macular bundle as a sensitive region in myopic development.
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DOI：
10.1038/s41433-021-01892-5
发表时间：
2023-02
期刊：
Eye (London, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.9
作者：
通讯作者：
--
影响因子：
4.4
作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
通讯作者：
Sarraf, David
影响因子：
3
作者：
Nicolini N;Tombolini B;Barresi C;Pignatelli F;Lattanzio R;Bandello F;Cicinelli MV
通讯作者：
Cicinelli MV
影响因子：
4.4
作者：
Kim, Gyu-Nam;Lee, Eun Ji;Kim, Tae-Woo
通讯作者：
Kim, Tae-Woo