Oral fluid testing for drugs of abuse.
Oral fluid testing for drugs of abuse.
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DOI：
10.1373/clinchem.2008.108670
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发表时间：
2009-11
影响因子：
9.3
通讯作者：
Huestis MA
中科院分区：
文献类型：
--
作者：
Bosker WM;Huestis MA
口服液（OF）是一种令人兴奋的替代矩阵，用于监测工作场所药物滥用，临床毒理学，刑事司法和药物影响下驾驶（DUID）计划。在过去的5年中，在OF采集、收集点检测设备以及筛选和确认方法方面取得了科技进步。提出了由药物滥用和精神健康服务管理局进行工作场所OF测试的指导方针，由欧盟在药物、酒精和药物影响下驾驶（DRUID）计划进行DUID测试的指导方针，以及DUID研究的标准化。虽然OF检测现在在许多监测项目中很常见，但目前最大的限制是缺乏可用于指导解释的受控药物管理研究。这篇综述概述了测试的优点和局限性，以及在过去5年中在大麻素、阿片类药物、安非他明、可卡因和苯二氮卓类药物的收集、筛选、确认和解释方面的进展。我们研究了对照药物管理研究、免疫分析和色谱方法、收集设备、收集点测试设备的性能以及of测试的最新应用。药物滥用和精神健康服务管理局推迟了of检测的批准，因为关于药物of处置的问题尚未解决，收集设备的性能和检测分析需要改进。在这里，我们记录了在使用of方面取得的许多进步。需要进一步的研究来确定新的生物标志物，确定药物检测窗口，表征掺假技术，并评估分析物的稳定性。然而，毫无疑问，OF作为药物监测的替代矩阵具有多种优势，并且在DUID，治疗，工作场所和刑事司法计划中发挥重要作用。
Oral fluid (OF) is an exciting alternative matrix for monitoring drugs of abuse in workplace, clinical toxicology, criminal justice, and driving under the influence of drugs (DUID) programs. During the last 5 years, scientific and technological advances in OF collection, point-of-collection testing devices, and screening and confirmation methods were achieved. Guidelines were proposed for workplace OF testing by the Substance Abuse and Mental Health Services Administration, DUID testing by the European Union’s Driving under the Influence of Drugs, Alcohol and Medicines (DRUID) program, and standardization of DUID research. Although OF testing is now commonplace in many monitoring programs, the greatest current limitation is the scarcity of controlled drug administration studies available to guide interpretation. This review outlines OF testing advantages and limitations, and the progress in OF that has occurred during the last 5 years in collection, screening, confirmation, and interpretation of cannabinoids, opioids, amphetamines, cocaine, and benzodiazepines. We examine controlled drug administration studies, immunoassay and chromatographic methods, collection devices, point-of-collection testing device performance, and recent applications of OF testing. Substance Abuse and Mental Health Services Administration approval of OF testing was delayed because questions about drug OF disposition were not yet resolved, and collection device performance and testing assays required improvement. Here, we document the many advances achieved in the use of OF. Additional research is needed to identify new bio-markers, determine drug detection windows, characterize OF adulteration techniques, and evaluate analyte stability. Nevertheless, there is no doubt that OF offers multiple advantages as an alternative matrix for drug monitoring and has an important role in DUID, treatment, workplace, and criminal justice programs.
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影响因子：
2.2
作者：
Cooper, G;Wilson, L;Hand, C
通讯作者：
Hand, C
DOI：
10.1111/j.1365-2125.1991.tb05550.x
发表时间：
1991-04-01
影响因子：
3.4
作者：
CHEN, ZR;SOMOGYI, AA;BOCHNER, F
通讯作者：
BOCHNER, F
影响因子：
2.5
作者：
Cone, Edward J.;Clarke, Joe;Tsanaclis, Lolita
通讯作者：
Tsanaclis, Lolita
影响因子：
2
作者：
Cámpora, P;Bermejo, AM;Fernández, P
通讯作者：
Fernández, P
影响因子：
2.2
作者：
Concheiro, Marta;de Castro, Ana;Lopez-Rivadulla, Manuel
通讯作者：
Lopez-Rivadulla, Manuel