Socioeconomic disadvantage, chronic stress, and proinflammatory phenotype: an integrative data analysis across the lifecourse.
Socioeconomic disadvantage, chronic stress, and proinflammatory phenotype: an integrative data analysis across the lifecourse.
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DOI：
10.1093/pnasnexus/pgac219
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发表时间：
2022-09
期刊：
影响因子：
--
通讯作者：
Miller, Gregory E.
中科院分区：
文献类型：
--
作者：
Lam, Phoebe H.;Chen, Edith;Chiang, Jessica J.;Miller, Gregory E.
社会经济劣势给许多慢性疾病带来风险，理论强调慢性心理压力和炎症过程的改变是关键途径。具体来说，不利条件会增加慢性应激，这可能会促进一种促炎表型，其特征是免疫细胞对挑战产生夸大的细胞因子反应，对抑制信号不那么敏感。重要的是，生命历程观点强调，这种免疫改变应该在生命早期的敏感时期更有效，因为身体组织对环境输入具有高度可塑性。然而，检查这些命题是资源密集型的，因为它们需要细胞培养方法来模拟功能性炎症活动，广泛的年龄范围和纵向数据。在这里，我们整合了来自5个独立研究的数据，创建了1607个个体的多样化样本（960个纵向数据，8至64岁，359个亚洲人，205个黑人和151个拉丁裔/a）。利用由此产生的生命历程数据，对不利条件和压力的丰富访谈评估，以及对炎症的体外评估，我们研究了两个问题：(1)慢性压力是否说明不利条件和促炎表型之间的联系？(2)是否存在一个炎症反应对不利条件和慢性应激更敏感的发育时期？劣势与较高的慢性应激有关，这与促炎表型横断面、纵向和1.5至2年的预期变化有关。与敏感期假说一致，这些间接关联的强度在前几十年最强，并在整个生命过程中下降。这些发现强调了在检查健康差异时采取生命历程观点的重要性。
Socioeconomic disadvantage confers risk for many chronic illnesses, and theories have highlighted chronic psychological stress and alterations to inflammatory processes as key pathways. Specifically, disadvantage can heighten chronic stress, which may promote a proinflammatory phenotype characterized by immune cells mounting exaggerated cytokine responses to challenge and being less sensitive to inhibitory signals. Importantly, lifecourse perspectives emphasize that such immune alterations should be more potent earlier in life during a sensitive period when bodily tissues are highly plastic to environmental inputs. However, examining these propositions is resource intensive, as they require cell-culturing approaches to model functional inflammatory activities, a wide age range, and longitudinal data. Here, we integrated data from five independent studies to create a diverse sample of 1,607 individuals (960 with longitudinal data; 8 to 64 years old; 359 Asian, 205 Black, and 151 Latino/a). Leveraging the resulting lifecourse data, rich interview assessments of disadvantage and stress, and ex vivo assessments of inflammation, we examined two questions: (1) Does chronic stress account for the link between disadvantage and proinflammatory phenotype? (2) Is there a developmental period during which inflammatory responses are more sensitive to disadvantage and chronic stress? Disadvantage was associated with higher chronic stress, which was linked with a proinflammatory phenotype cross-sectionally, longitudinally, and in terms of prospective change across 1.5 to 2 years. Consistent with the sensitive period hypothesis, the magnitude of these indirect associations was strongest in earlier decades and declined across the lifecourse. These findings highlight the importance of taking a lifecourse perspective in examining health disparities.
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影响因子：
14.2
作者：
Chen, Edith;Hanson, Margaret D.;Miller, Gregory E.
通讯作者：
Miller, Gregory E.
影响因子：
15.8
作者：
Danesh, John;Kaptoge, Stephen;Mann, Andrea G.;Sarwar, Nadeem;Wood, Angela;Angleman, Sara B.;Wensley, Frances;Higgins, Julian P. T.;Lennon, Lucy;Eiriksdottir, Gudny;Rumley, Ann;Whincup, Peter H.;Lowe, Gordon D. O.;Gudnason, Vilmundur
通讯作者：
Gudnason, Vilmundur
影响因子：
4.2
作者：
Chiang, Jessica J.;Chen, Edith;Miller, Gregory E.
通讯作者：
Miller, Gregory E.
影响因子：
8
作者：
Chen, Edith;Miller, Gregory E.;Brauer, Michael
通讯作者：
Brauer, Michael
影响因子：
105.7
作者：
Danesh, J;Whincup, P;Pepys, MB
通讯作者：
Pepys, MB