Marker-dependent associations among oxidative stress, growth and survival during early life in a wild mammal.
Marker-dependent associations among oxidative stress, growth and survival during early life in a wild mammal.
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DOI：
10.1098/rspb.2016.1407
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发表时间：
2016-10-12
期刊：
影响因子：
--
通讯作者：
Nussey DH
中科院分区：
文献类型：
--
作者：
Christensen LL;Selman C;Blount JD;Pilkington JG;Watt KA;Pemberton JM;Reid JM;Nussey DH
氧化应激（OS）被假设为介导生活史权衡的关键生理机制，但来自经历自然环境变化的野生种群的证据是有限的。我们测试的假设，增加早期生活的增长率增加OS，OS增加减少第一个冬天的生存，在野生Soay羊（绵羊）羔羊。我们测量了四个连续队列的生长速度和第一个冬天的生存率，并测量了血液样本中的两个氧化损伤标志物（丙二醛（MDA），蛋白质羰基（PC））和两个抗氧化剂（AOX）保护标志物（总AOX能力（TAC），超氧化物歧化酶（SOD））。羔羊生长速度加快与MDA增加呈弱相关，但与其他三个标记物的变化无关。具有较高的SOD活性的羔羊更有可能生存的第一个冬天，是男性，但不是女性羔羊PC浓度较低。存活率不随MDA或总TAC而变化。因此，一些OS标志物支持OS与生长和生存相关的关键预测，但其他标志物则不支持。这表明，不同的标志物捕捉不同方面的个人氧化状态，生理和健身之间的复杂关系，以及有关OS的生活史变化的总体假设不能支持或通过研究个别标志物反驳。
Oxidative stress (OS) is hypothesized to be a key physiological mechanism mediating life-history trade-offs, but evidence from wild populations experiencing natural environmental variation is limited. We tested the hypotheses that increased early life growth rate increases OS, and that increased OS reduces first-winter survival, in wild Soay sheep (Ovis aries) lambs. We measured growth rate and first-winter survival for four consecutive cohorts, and measured two markers of oxidative damage (malondialdehyde (MDA), protein carbonyls (PC)) and two markers of antioxidant (AOX) protection (total AOX capacity (TAC), superoxide dismutase (SOD)) from blood samples. Faster lamb growth was weakly associated with increased MDA, but not associated with variation in the other three markers. Lambs with higher SOD activity were more likely to survive their first winter, as were male but not female lambs with lower PC concentrations. Survival did not vary with MDA or total TAC. Key predictions relating OS to growth and survival were therefore supported in some OS markers, but not others. This suggests that different markers capture different aspects of the complex relationships between individual oxidative state, physiology and fitness, and that overarching hypotheses relating OS to life-history variation cannot be supported or refuted by studying individual markers.
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