Estimated US Pediatric Hospitalizations and School Absenteeism Associated With Accelerated COVID-19 Bivalent Booster Vaccination.
Estimated US Pediatric Hospitalizations and School Absenteeism Associated With Accelerated COVID-19 Bivalent Booster Vaccination.
复制标题
DOI：
10.1001/jamanetworkopen.2023.13586
复制
发表时间：
2023-05-01
影响因子：
13.8
通讯作者：
Galvani, Alison P.
中科院分区：
文献类型：
--
作者：
Fitzpatrick, Meagan C.;Moghadas, Seyed M.;Vilches, Thomas N.;Shah, Arnav;Pandey, Abhishek;Galvani, Alison P.
在美国，加速COVID-19二价加强疫苗接种是否与儿科住院和学生缺勤的结果减少有关？在这个使用美国人口估计的决策分析模型中，模拟模型显示，从2022年10月1日到2023年3月31日，实现与季节性流感疫苗接种类似的接种的加强运动可以防止估计10019例儿科住院和5448694天的缺课。这些研究结果表明，尽管COVID-19预防策略通常侧重于老年人，但针对儿童的助推运动可能会带来巨大的好处。COVID-19对儿科人群的不良后果包括疾病和住院，导致缺课。所有年龄段符合条件的个人的加强疫苗接种可以促进健康和入学率。评估在普通人群中加速COVID-19二价加强疫苗接种是否与减少儿科住院和缺课有关。在该决策分析模型中，COVID-19传播的模拟模型拟合了2020年10月1日至2022年9月30日报告的发病率数据，模拟了2022年10月1日至2023年3月31日的结果。传播模型包括整个年龄分层的美国人群，结局模型包括18岁以下的儿童。模拟加速二价COVID-19加强疫苗接种活动的情景，以使所有年龄组的合资格人群的接种量达到2020年至2021年季节性流感疫苗接种的年龄特异性接种量的一半或相似。主要结果是在加速二价加强疫苗接种运动模拟情景下，0至17岁儿童避免的估计住院、重症监护室入院和隔离症状感染天数，以及5至17岁儿童避免的估计旷课天数。在5至17岁的儿童中，COVID-19双价加强疫苗接种活动实现了与流感疫苗接种类似的年龄特异性覆盖率，估计可以避免因COVID-19疾病而缺课5 448 694天（95%可信区间[CrI]，4 936 933-5 957 507天）。此外，在0至17岁的儿科人群中，加强运动可以预防估计10 019例（95% CrI，8756-11 278）住院，其中估计有2645例（95% CrI，2152-3147）需要重症监护。一个不太雄心勃勃的加强运动，只有50%的年龄特定的接种流感疫苗的符合条件的个人可以避免估计2875926（95%CrI，2 524 351-3 332 783）天，估计5至17岁儿童旷课5 791（95%CrI，4391-6932）0 - 17岁儿童住院治疗，其中1397例（95%CrI，846-1948）估计需要重症监护。在这个决策分析模型中，合格年龄组中二价加强疫苗接种的增加与儿科人群住院和缺课的减少相关。这些研究结果表明，尽管COVID-19预防策略通常侧重于老年人，但针对儿童的助推运动可能会带来巨大的好处。该决策分析模型估计符合条件的美国人群中COVID-19二价加强疫苗接种率的增加是否与儿童住院和缺课的减少有关。
Would accelerated COVID-19 bivalent booster vaccination uptake in the US be associated with decreased outcomes of pediatric hospitalizations and student absenteeism? In this decision analytical model using US population estimates, a simulation model revealed that booster campaigns achieving an uptake similar to seasonal influenza vaccination could have prevented an estimated 10 019 pediatric hospitalizations and 5 448 694 days of school absenteeism from October 1, 2022, to March 31, 2023. These findings suggest that although COVID-19 prevention strategies often focus on older populations, the benefits of booster campaigns for children may be substantial. Adverse outcomes of COVID-19 in the pediatric population include disease and hospitalization, leading to school absenteeism. Booster vaccination for eligible individuals across all ages may promote health and school attendance. To assess whether accelerating COVID-19 bivalent booster vaccination uptake across the general population would be associated with reduced pediatric hospitalizations and school absenteeism. In this decision analytical model, a simulation model of COVID-19 transmission was fitted to reported incidence data from October 1, 2020, to September 30, 2022, with outcomes simulated from October 1, 2022, to March 31, 2023. The transmission model included the entire age-stratified US population, and the outcome model included children younger than 18 years. Simulated scenarios of accelerated bivalent COVID-19 booster campaigns to achieve uptake that was either one-half of or similar to the age-specific uptake observed for 2020 to 2021 seasonal influenza vaccination in the eligible population across all age groups. The main outcomes were estimated hospitalizations, intensive care unit admissions, and isolation days of symptomatic infection averted among children aged 0 to 17 years and estimated days of school absenteeism averted among children aged 5 to 17 years under the accelerated bivalent booster campaign simulated scenarios. Among children aged 5 to 17 years, a COVID-19 bivalent booster campaign achieving age-specific coverage similar to influenza vaccination could have averted an estimated 5 448 694 (95% credible interval [CrI], 4 936 933-5 957 507) days of school absenteeism due to COVID-19 illness. In addition, the booster campaign could have prevented an estimated 10 019 (95% CrI, 8756-11 278) hospitalizations among the pediatric population aged 0 to 17 years, of which 2645 (95% CrI, 2152-3147) were estimated to require intensive care. A less ambitious booster campaign with only 50% of the age-specific uptake of influenza vaccination among eligible individuals could have averted an estimated 2 875 926 (95% CrI, 2 524 351-3 332 783) days of school absenteeism among children aged 5 to 17 years and an estimated 5791 (95% CrI, 4391-6932) hospitalizations among children aged 0 to 17 years, of which 1397 (95% CrI, 846-1948) were estimated to require intensive care. In this decision analytical model, increased uptake of bivalent booster vaccination among eligible age groups was associated with decreased hospitalizations and school absenteeism in the pediatric population. These findings suggest that although COVID-19 prevention strategies often focus on older populations, the benefits of booster campaigns for children may be substantial. This decision analytical model estimates whether increases in COVID-19 bivalent booster vaccination uptake in the eligible US population would be associated with reduced hospitalizations and school absenteeism among children.
登录
查看更多内容
DOI：
10.1126/science.abm0620
发表时间：
2022-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1093/cid/ciab079
发表时间：
2021-12-16
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Moghadas SM;Vilches TN;Zhang K;Wells CR;Shoukat A;Singer BH;Meyers LA;Neuzil KM;Langley JM;Fitzpatrick MC;Galvani AP
通讯作者：
Galvani AP
影响因子：
8
作者：
Gassman-Pines, Anna;Ananat, Elizabeth Oltmans;Fitz-Henley, John, II
通讯作者：
Fitz-Henley, John, II
影响因子：
82.9
作者：
Chemaitelly, Hiam;Yassine, Hadi M.;Abu-Raddad, Laith J.
通讯作者：
Abu-Raddad, Laith J.
DOI：
10.1038/s41577-022-00716-1
发表时间：
2022-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--