A simultaneous modulation of reactive and proactive inhibition processes by anodal tDCS on the right inferior frontal cortex.
A simultaneous modulation of reactive and proactive inhibition processes by anodal tDCS on the right inferior frontal cortex.
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DOI：
10.1371/journal.pone.0113537
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Miniussi C
中科院分区：
文献类型：
--
作者：
Cunillera T;Fuentemilla L;Brignani D;Cucurell D;Miniussi C
主动和反应性抑制过程是执行功能的基本部分，允许一个人在必要时停止不适当的反应，并根据任务目标长期调整表现。在当前的研究中，我们在一个任务中同时操纵反应性和主动性抑制机制，并研究了通过阳极经颅直流电刺激(TDC)增加右侧额叶下部皮质(RIFC)参与的受试者内部效应。我们的结果表明，当调节RIFC的神经活动时，这两种认知机制同时增强。因此，阳极tdcs的应用增加了GO试验的反应时间，表明主动抑制可能增加。同时，作为抑制过程的隐蔽指标的停止信号反应时间也有所减少，表明反应抑制效果有所改善。总而言之，目前的结果模式证实了RIFC参与了主动抑制和反应性抑制这两种形式的抑制过程，并提供了两种过程可以在大脑中同时运行的证据。
Proactive and reactive inhibitory processes are a fundamental part of executive functions, allowing a person to stop inappropriate responses when necessary and to adjust performance in in a long term in accordance to the goals of a task. In the current study, we manipulate, in a single task, both reactive and proactive inhibition mechanisms, and we investigate the within-subjects effect of increasing, by means of anodal transcranial direct current stimulation (tDCS), the involvement of the right inferior frontal cortex (rIFC). Our results show a simultaneous enhancement of these two cognitive mechanisms when modulating the neural activity of rIFC. Thus, the application of anodal tDCS increased reaction times on Go trials, indicating a possible increase in proactive inhibition. Concurrently, the stop-signal reaction time, as a covert index of the inhibitory process, was reduced, demonstrating an improvement in reactive inhibition. In summary, the current pattern of results validates the engagement of the rIFC in these two forms of inhibitory processes, proactive and reactive inhibition and it provides evidence that both processes can operate concurrently in the brain.
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