Variety of horizontal cell gap junctions in the rabbit retina.
Variety of horizontal cell gap junctions in the rabbit retina.
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DOI：
10.1016/j.neulet.2012.01.010
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发表时间：
2012-02-29
影响因子：
2.5
通讯作者：
Kim IB
中科院分区：
文献类型：
--
作者：
Cha J;Kim HL;Pan F;Chun MH;Massey SC;Kim IB
在兔子的视网膜中，有两种类型的水平细胞（HC）。无轴突 A 型 HC 通过外丛状层 (OPL) 中的连接蛋白 50 (Cx50) 间隙连接形成耦合网络。轴突轴承 B 型 HC 形成两个独立的耦合网络；通过间隙连接的树突网络由未知的 Cx 组成，通过 Cx57 的轴突末端网络组成。本研究的目的是在细胞和亚细胞水平上检查兔 HC 中 Cx50 和 Cx57 间隙连接的定位和形态特征。结果表明，由Cx50或Cx57组成的每个间隙连接都表现出明显的特征。较大的 Cx50 间隙连接比较小的 Cx50 间隙连接位于更近端。两个 Cx50 斑块均形成对称的同型间隙连接，但一些小的斑块具有不对称的外观，表明存在异型间隙连接或半通道。相比之下，Cx57 间隙连接发现于 OPL 的更远端部分，但从未发现于进入杆状小球的轴突末端，并且它们完全是同型的。有趣的是，大约一半的 Cx57 间隙连接似乎是内陷的。 Cx50 和 Cx57 间隙连接的这些独特特征显示了 HC 间隙连接的多样性，并可能提供对不同类型 HC 功能的深入了解。
In the rabbit retina, there are two types of horizontal cell (HC). The axonless A-type HCs form a coupled network via connexin 50 (Cx50) gap junctions in the outer plexiform layer (OPL). The axon-bearing B-type HCs form two independent coupled networks; the dendritic network via gap junctions consisted of unknown Cx and the axon terminal network via Cx57. The present study was conducted to examine the localization and morphological features of Cx50 and Cx57 gap junctions in rabbit HCs at cellular and subcellular levels. The results showed that each gap junction composed of Cx50 or Cx57 showed distinct features. The larger Cx50 gap junctions were located more proximally than the smaller Cx50 gap junctions. Both Cx50 plaques formed symmetrical homotypic gap junctions, but some small ones had an asymmetrical appearance, suggesting the presence of heterotypic gap junctions or hemichannels. In contrast, Cx57 gap junctions were found in the more distal part of the OPL but never on the axon terminal endings entering the rod spherules, and they were exclusively homotypic. Interestingly, about half of Cx57 gap junctions appeared to be invaginated. These distinct features of Cx50 and Cx57 gap junctions show variety of HC gap junctions and may provide insights into the function of different types of HCs.
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影响因子：
56.9
作者：
Kamermans, M;Fahrenfort, I;Weiler, R
通讯作者：
Weiler, R
影响因子：
3.4
作者：
Lo, WK;Shaw, AP;Tigges, M
通讯作者：
Tigges, M
DOI：
10.1007/bf01188041
发表时间：
1990-10-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
RAVIOLA, E;DACHEUX, RF
通讯作者：
DACHEUX, RF
影响因子：
1.9
作者：
BLOOMFIELD, SA;XIN, DY;PERSKY, SE
通讯作者：
PERSKY, SE
影响因子：
5.5
作者：
BAYLOR, DA;FUORTES, MGF;OBRYAN, PM
通讯作者：
OBRYAN, PM