A natural timeless polymorphism allowing circadian clock synchronization in "white nights".
A natural timeless polymorphism allowing circadian clock synchronization in "white nights".
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DOI：
10.1038/s41467-022-29293-6
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发表时间：
2022-03-31
影响因子：
16.6
通讯作者：
Stanewsky R
中科院分区：
文献类型：
--
作者：
Lamaze A;Chen C;Leleux S;Xu M;George R;Stanewsky R
日常的时间组织提供了一个健身优势，是由环境节奏和生物钟之间的相互作用。虽然光暗周期可以使生物钟同步，但目前尚不清楚只经历弱环境线索的动物如何处理这个问题。和人类一样，果蝇起源于撒哈拉以南的非洲，向北扩散到极圈，经历漫长的夏日甚至持续的光照（LL）。LL由于持续激活光敏色素而破坏生物钟功能，从而诱导生物钟蛋白TIMELESS（TIM）的降解，但温度循环能够克服LL的这些有害影响。我们在这里表明，要发生这种情况，需要一个最近进化的自然永恒的等位基因（ls-tim），除了S-TIM，唯一的形式编码的古老的s-tim等位基因编码的光敏感性较低的L-TIM。我们发现，只有LS-蒂姆苍蝇可以同步他们的行为，典型的北方欧洲夏季的半自然条件下，这表明这种功能的增益是推动向北LS-蒂姆传播。果蝇属起源于撒哈拉以南非洲，向北传播至极圈，在那里它们会经历漫长的夏季日照甚至持续的光照。在这里，作者表明，一种TIMELESS蛋白质使苍蝇能够将它们的行为活动与漫长的夏日同步
Daily temporal organisation offers a fitness advantage and is determined by an interplay between environmental rhythms and circadian clocks. While light:dark cycles robustly synchronise circadian clocks, it is not clear how animals experiencing only weak environmental cues deal with this problem. Like humans, Drosophila originate in sub-Saharan Africa and spread North up to the polar circle, experiencing long summer days or even constant light (LL). LL disrupts clock function, due to constant activation of CRYPTOCHROME, which induces degradation of the clock protein TIMELESS (TIM), but temperature cycles are able to overcome these deleterious effects of LL. We show here that for this to occur a recently evolved natural timeless allele (ls-tim) is required, encoding the less light-sensitive L-TIM in addition to S-TIM, the only form encoded by the ancient s-tim allele. We show that only ls-tim flies can synchronise their behaviour to semi-natural conditions typical for Northern European summers, suggesting that this functional gain is driving the Northward ls-tim spread. The genus Drosophila originate in subSaharan Africa and spread North up to the polar circle where they experience long days in the summer or even constant light. Here, the authors show that a form of the TIMELESS protein enables flies to synchronise their behavioural activity to long summer days
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DOI：
10.1016/j.cub.2018.04.016
发表时间：
2018-06-04
期刊：
Current biology : CB
影响因子：
--
作者：
Ogueta M;Hardie RC;Stanewsky R
通讯作者：
Stanewsky R
影响因子：
56.9
作者：
Koh, Kyunghee;Zheng, Xiangzhong;Sehgal, Amita
通讯作者：
Sehgal, Amita
影响因子：
2.4
作者：
Levine JD;Funes P;Dowse HB;Hall JC
通讯作者：
Hall JC
影响因子：
3.5
作者：
Beauchamp, Marta;Bertolini, Enrico;Helfrich-Foerster, Charlotte
通讯作者：
Helfrich-Foerster, Charlotte
影响因子：
9.2
作者：
Ogueta, Maite;Hardie, Roger C.;Stanewsky, Ralf
通讯作者：
Stanewsky, Ralf