Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users.
Mismatch negativity and adaptation measures of the late auditory evoked potential in cochlear implant users.
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DOI：
10.1016/j.heares.2010.11.007
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发表时间：
2011-05
期刊：
影响因子：
2.8
通讯作者：
Fu, Qian-Jie
中科院分区：
文献类型：
--
作者：
Zhang, Fawen;Hammer, Theresa;Banks, Holly-Lolan;Benson, Chelsea;Xiang, Jing;Fu, Qian-Jie
更好地了解人工耳蜗（CI）患者语言表现大变异性的神经相关性，可能使我们找到进一步提高人工耳蜗效益的解决方案。本研究对10名CI使用者的失配负性（MMN）和后期听觉诱发电位（LAEP）的适应进行了研究。采用语音音节/da/和1 khz音调爆发来检测LAEP的适应情况。根据后3个刺激诱发的LAEP的N1-P2平均振幅和第一个刺激诱发的振幅计算LAEP的适应量。对于MMN记录，标准刺激（1khz音）和偏差刺激（2khz音）在古怪条件下呈现。此外，离常者单独出现在对照条件下。MMN由控制条件下的偏差响应减去古怪条件下的偏差响应得到。结果表明，良好的CI表现者比中差表现者表现出更突出的LAEP适应。语音表现与LAEP对1 khz音爆发的适应量显著相关。表现良好的人表现出较大的mmn，而中差的人表现出较小或没有mmn。中差表现者的异常电生理结果表明，长期耳聋不仅在听觉皮质层面造成损害，而且在认知层面造成损害。
A better understanding of the neural correlates of large variability in cochlear implant (CI) patients’ speech performance may allow us to find solutions to further improve CI benefits. The present study examined the mismatch negativity (MMN) and the adaptation of the late auditory evoked potential (LAEP) in 10 CI users. The speech syllable /da/ and 1-kHz tone burst were used to examine the LAEP adaptation. The amount of LAEP adaptation was calculated according to the averaged N1-P2 amplitude for the LAEPs evoked by the last 3 stimuli and the amplitude evoked by the first stimulus. For the MMN recordings, the standard stimulus (1-kHz tone) and the deviant stimulus (2-kHz tone) were presented in an oddball condition. Additionally, the deviants alone were presented in a control condition. The MMN was derived by subtracting the response to the deviants in the control condition from the oddball condition. Results showed that good CI performers displayed a more prominent LAEP adaptation than moderate-to-poor performers. Speech performance was significantly correlated to the amount of LAEP adaptation for the 1-kHz tone bursts. Good performers displayed large MMNs and moderate-to-poor performers had small or absent MMNs. The abnormal electrophysiological findings in moderate-to-poor performers suggest that long-term deafness may cause damage not only at the auditory cortical level, but also at the cognitive level.
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影响因子：
2.4
作者：
Burkard, R;McGee, J;Walsh, EJ
通讯作者：
Walsh, EJ
影响因子：
2
作者：
Babalian, AL;Ryugo, DK;Rouiller, EM
通讯作者：
Rouiller, EM
影响因子：
2.8
作者：
BOETTCHER, FA;SALVI, RJ;SAUNDERS, SS
通讯作者：
SAUNDERS, SS
DOI：
10.1016/0013-4694(87)90185-4
发表时间：
1987-02-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
BOURBON, WT;WILL, KW;PAPANICOLAOU, AC
通讯作者：
PAPANICOLAOU, AC
DOI：
10.1016/0013-4694(70)90183-5
发表时间：
1970-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
FRUHSTOR.H;SOVERI, P;JARVILEH.T
通讯作者：
JARVILEH.T