Decoding the information structure underlying the neural representation of concepts.
Decoding the information structure underlying the neural representation of concepts.
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解码概念的神经表征背后的信息结构。
DOI：
10.1073/pnas.2108091119
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发表时间：
2022-02-08
影响因子：
11.1
通讯作者：
Binder JR
中科院分区：
文献类型：
--
作者：
Fernandino L;Tong JQ;Conant LL;Humphries CJ;Binder JR
将单个对象或事件识别为某类成员的能力（例如，“刀”、“狗”或“党”）是人类认知的一个基本方面。它使我们能够快速访问有关新遇到的对象或事件的丰富信息，并使用它来指导我们的行为。这些信息在大脑中是如何表达的？我们使用功能性磁共振成像来分析与数百个熟悉概念相对应的大脑活动模式，并定量描述这些模式的信息结构。我们的研究结果表明，概念知识存储的神经活动模式，编码的感觉运动和情感信息的每个概念，相反的长期持有的想法，概念表征是独立的感觉运动的经验。概念知识背后的表征代码的本质仍然是认知神经科学中一个未解决的主要问题。我们评估了在何种程度上不同的表征系统有助于实例化的词汇概念在高层次，heteromodal皮质区以前与语义认知。我们发现，词汇语义信息可以可靠地解码，从广泛的异模态皮质区在额叶，顶叶和颞叶皮层。在这些领域中的大多数，我们发现基于经验的表征结构（即，编码关于感觉运动、情感和现象体验的其他特征的信息），几乎没有独立分类或分布组织的证据。这些结果被发现独立的对象和事件的概念。我们的研究结果表明，在异模态皮层的概念表征的基础上，至少在一定程度上，经验信息。他们还揭示，在大多数异质模态区域，事件概念具有更多的异质表征（即，它们比对象概念更容易解码），以及传统“语义中枢”之外的其他区域，特别是后扣带回和楔前叶，也有助于语义认知。
The ability to identify individual objects or events as members of a kind (e.g., “knife,” “dog,” or “party”) is a fundamental aspect of human cognition. It allows us to quickly access a wealth of information pertaining to a newly encountered object or event and use it to guide our behavior. How is this information represented in the brain? We used functional MRI to analyze patterns of brain activity corresponding to hundreds of familiar concepts and quantitatively characterized the informational structure of these patterns. Our results indicate that conceptual knowledge is stored as patterns of neural activity that encode sensory-motor and affective information about each concept, contrary to the long-held idea that concept representations are independent of sensory-motor experience. The nature of the representational code underlying conceptual knowledge remains a major unsolved problem in cognitive neuroscience. We assessed the extent to which different representational systems contribute to the instantiation of lexical concepts in high-level, heteromodal cortical areas previously associated with semantic cognition. We found that lexical semantic information can be reliably decoded from a wide range of heteromodal cortical areas in the frontal, parietal, and temporal cortex. In most of these areas, we found a striking advantage for experience-based representational structures (i.e., encoding information about sensory-motor, affective, and other features of phenomenal experience), with little evidence for independent taxonomic or distributional organization. These results were found independently for object and event concepts. Our findings indicate that concept representations in the heteromodal cortex are based, at least in part, on experiential information. They also reveal that, in most heteromodal areas, event concepts have more heterogeneous representations (i.e., they are more easily decodable) than object concepts and that other areas beyond the traditional “semantic hubs” contribute to semantic cognition, particularly the posterior cingulate gyrus and the precuneus.
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影响因子：
5.4
作者：
Hoffman P;McClelland JL;Lambon Ralph MA
通讯作者：
Lambon Ralph MA
影响因子：
5.7
作者：
Handjaras, Giacomo;Ricciardi, Emiliano;Pietrini, Pietro
通讯作者：
Pietrini, Pietro
影响因子：
29.9
作者：
Chen, Lang;Ralph, Matthew A. Lambon;Rogers, Timothy T.
通讯作者：
Rogers, Timothy T.
影响因子：
3.7
作者：
Carota, Francesca;Kriegeskorte, Nikolaus;Pulvermuller, Friedemann
通讯作者：
Pulvermuller, Friedemann
影响因子：
3.7
作者：
Fernandino, Leonardo;Binder, Jeffrey R.;Seidenberg, Mark S.
通讯作者：
Seidenberg, Mark S.