White-opaque switching in Candida albicans.

White-opaque switching in Candida albicans.
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DOI:
10.1016/j.mib.2009.09.010
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发表时间:
2009-12
影响因子:
5.4
通讯作者:
Johnson, Alexander D.
Johnson, Alexander D.
中科院分区:
生物学2区
文献类型:
--
作者:
Lohse, Matthew B.;Johnson, Alexander D.

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人类酵母菌白色念珠菌经历了两种不同类型的细胞之间的表观遗传转换,称为白色和不透明。这两种细胞类型在许多方面不同,包括它们的细胞和菌落形态,它们的代谢状态,它们的交配行为,它们在宿主中的偏好小生境,以及它们与宿主免疫系统的相互作用。这两种细胞类型中的每一种都可以遗传许多代,它们之间的转换似乎是随机的;然而,环境因素可以显着改变转换的频率。我们回顾了最近的工作,白色不透明开关,包括建立转录电路的开关,识别环境信号,影响开关率,新发现的差异,两种类型的细胞,和参与的白色不透明开关在生物膜形成。我们还回顾了最近的猜测的演变和适应价值的白色不透明开关。
The human commensal yeast Candida albicans undergoes an epigenetic switch between two distinct types of cells, referred to as white and opaque. These two cell types differ in many respects, including their cell and colony morphologies, their metabolic states, their mating behaviors, their preferred niches in the host, and their interactions with the host immune system. Each of the two cell types is heritable for many generations and switching between them appears stochastic; however, environmental cues can significantly alter the frequency of switching. We review recent work on white-opaque switching, including the establishment of the transcriptional circuit underlying this switch, the identification of environmental signals that affect switching rates, newly discovered differences between the two types of cells, and the involvement of white-opaque switching in biofilm formation. We also review recent speculation on the evolution and adaptive value of white-opaque switching.
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