Head mounted DMD based projection system for natural and prosthetic visual stimulation in freely moving rats.
Head mounted DMD based projection system for natural and prosthetic visual stimulation in freely moving rats.
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DOI：
10.1038/srep34873
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发表时间：
2016-10-12
影响因子：
4.6
通讯作者：
Mandel Y
中科院分区：
文献类型：
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作者：
Arens-Arad T;Farah N;Ben-Yaish S;Zlotnik A;Zalevsky Z;Mandel Y
盲人视力恢复的新技术不断被开发。这些新兴技术中有许多是基于特定波长的高强度光模式的投影，因此需要开发专门的投影系统。在这里，我们提出并描述了一种新的投影系统，该系统满足大鼠人工视网膜刺激的要求，并能够记录皮质反应。该系统基于一个定制的微型数字镜像设备（DMD），用于在可见光（525纳米）和近红外（915纳米）波长下进行图案投影，以及一个透镜潜望镜，用于将图案直接传递到动物的视网膜上。使用ZEMAX对系统进行了全面的表征，并研究了各种参数对获得的图像质量的影响。仿真结果表明，在顶点距离影响不大的情况下，获得了MTF大于0.8的图像。在最佳的瞳孔直径和较小的视场下获得了更高的图像质量。视觉皮层活动数据与模式投影同时记录，进一步强调了该系统在假肢视觉研究中的重要性。这种新颖的头戴式投影系统可能被证明是研究行为动物的自然和人工视觉的重要工具。
Novel technologies are constantly under development for vision restoration in blind patients. Many of these emerging technologies are based on the projection of high intensity light patterns at specific wavelengths, raising the need for the development of specialized projection systems. Here we present and characterize a novel projection system that meets the requirements for artificial retinal stimulation in rats and enables the recording of cortical responses. The system is based on a customized miniature Digital Mirror Device (DMD) for pattern projection, in both visible (525 nm) and NIR (915 nm) wavelengths, and a lens periscope for relaying the pattern directly onto the animal’s retina. Thorough system characterization and the investigation of the effect of various parameters on obtained image quality were performed using ZEMAX. Simulation results revealed that images with an MTF higher than 0.8 were obtained with little effect of the vertex distance. Increased image quality was obtained at an optimal pupil diameter and smaller field of view. Visual cortex activity data was recorded simultaneously with pattern projection, further highlighting the importance of the system for prosthetic vision studies. This novel head mounted projection system may prove to be a vital tool in studying natural and artificial vision in behaving animals.
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影响因子：
16.6
作者：
Reutsky-Gefen, Inna;Golan, Lior;Shoham, Shy
通讯作者：
Shoham, Shy
影响因子：
1.8
作者：
Prusky, GT;West, PWR;Douglas, RM
通讯作者：
Douglas, RM
影响因子：
7.7
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通讯作者：
Stryker MP
影响因子：
16.2
作者：
Helmchen, F;Fee, MS;Denk, W
通讯作者：
Denk, W
影响因子：
16.6
作者：
通讯作者：
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