Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials.
Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials.
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DOI：
10.1038/ncomms2980
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
我们以前已经开发了一种无线光伏视网膜假体，其中相机捕获的图像使用脉冲近红外光投射到视网膜上。视网膜下植入物中的每个像素直接将脉冲光转换为局部电流，以刺激附近的视网膜内层神经元。在这里，我们报告了像素大小为280，140和70μm的植入物植入正常和退化视网膜的大鼠视网膜下腔，在脉冲近红外光刺激下引起强烈的皮质反应。植入物诱发的eVEP比可见光诱发的VEP潜伏期短，其振幅随峰值辐照度和脉冲持续时间的增加而增加，在2- 20 Hz范围内随频率的增加而减小，与可见光反应相似。阵列的模块化设计允许大量像素的可扩展性，并且与易于植入相结合，为视网膜退行性疾病致盲患者的视力恢复提供了一种有前途的方法。
We have previously developed a wireless photovoltaic retinal prosthesis, in which camera-captured images are projected onto the retina using pulsed near-IR light. Each pixel in the subretinal implant directly converts pulsed light into local electric current to stimulate the nearby inner retinal neurons. Here we report that implants having pixel sizes of 280, 140 and 70μm implanted in the subretinal space in rats with normal and degenerate retina elicit robust cortical responses upon stimulation with pulsed near-IR light. Implant-induced eVEP has shorter latency than visible light-induced VEP, its amplitude increases with peak irradiance and pulse duration, and decreases with frequency in the range of 2-20Hz, similar to the visible light response. Modular design of the arrays allows scalability to a large number of pixels, and combined with the ease of implantation, offers a promising approach to restoration of sight in patients blinded by retinal degenerative diseases.
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