Genetic diversity of hepatitis C virus predicts recurrent disease after liver transplantation.
Genetic diversity of hepatitis C virus predicts recurrent disease after liver transplantation.
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DOI：
10.1016/j.virol.2010.03.040
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发表时间：
2010-07-05
期刊：
影响因子：
3.7
通讯作者：
Gretch DR
中科院分区：
文献类型：
--
作者：
Li H;Sullivan DG;Feuerborn N;McArdle S;Bekele K;Pal S;Yeh M;Carithers RL;Perkins JD;Gretch DR
大约20%接受肝移植治疗终末期丙型肝炎的患者在移植后的前24个月内迅速发展为严重的同种异体肝纤维化。在56例基因型1感染的终末期丙型肝炎患者中研究了肝移植前和肝移植后12个月的丙型肝炎病毒（HCV）变异，并通过系列肝活检随访移植后结局。在15例患者中，详细研究了移植前肝脏（n=15）、血清（n = 15）、外周血单个核细胞（n=13）和肝周淋巴结（n=10）中HCV的遗传多样性。我们的研究结果表明，移植前HCV基因多样性预测移植后复发性丙型肝炎的组织学结果。移植后轻度疾病复发与较高的遗传多样性显著相关，移植前和移植后时间点之间的多样性变化更大（p=0.004）。同时，移植前血清和肝脏之间的遗传差异与移植后轻度复发疾病的可能性较高相关（p=0.039）。
Approximately 20% of patients receiving liver transplants for end-stage hepatitis C rapidly develop severe allograph fibrosis within the first 24 months after transplant. Hepatitis C virus (HCV) variants were studied in 56 genotype 1-infected subjects with end-stage hepatitis C disease at the time before and 12-month after liver transplant, and post-transplant outcome was followed with serial liver biopsies. In 15 cases, pre-transplant HCV genetic diversity was studied in detail in liver (n=15), serum (n=15), peripheral blood mononuclear cells (n=13) and perihepatic lymph nodes (n=10). Our results revealed that pre-transplant HCV genetic diversity predicted the histological outcome of recurrent hepatitis C disease after transplant. Mild disease recurrence after transplant was significantly associated with higher genetic diversity, and greater diversity changes between the pre- and post-transplant time points (p=0.004). Meanwhile, pre-transplant genetic differences between serum and liver were related to a higher likelihood of development of mild recurrent disease after transplant (p=0.039).
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