Novel wave intensity analysis of arterial pulse wave propagation accounting for peripheral reflections.

Novel wave intensity analysis of arterial pulse wave propagation accounting for peripheral reflections.
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DOI:
10.1002/cnm.2602
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发表时间:
2014-02
影响因子:
2.1
通讯作者:
Weinberg PD
Weinberg PD
中科院分区:
工程技术3区
文献类型:
--
作者:
Alastruey J;Hunt AA;Weinberg PD

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我们提出了一种新的动脉脉搏波传播分析方法,该方法将传统的脉搏波强度分析与温克塞尔压力识别相结合,以考虑动脉脉搏波传播对周围波反射压力波形的影响。使用在兔体内 测量的血流动力学数据或在人体顺应性血管模型中数值产生的数据,我们发现传统的波强度分析识别出形成收缩中的主动脉压力和血流波形的主要波的时间、方向和大小,但无法识别外周反射的影响。这些反射持续了几个心动周期,并构成了大部分的压力波形,特别是在舒张期和收缩早期。忽略外周反射会导致对收缩早期无反射周期的错误指示,并导致(I)由PU-loop方法给出的升主动脉处的脉搏波速度的估计(误差9.5%)和(Ii)根据波强分布计算的到主要反射部位的通过时间(误差27%)的额外误差。当计入外围反射时,这些误差分别减少到1.3%和10%。利用我们的新分析,我们研究了血管顺应性和外周阻力对波强度、外周反射和起源于先前心脏周期的反射的影响。
We present a novel analysis of arterial pulse wave propagation that combines traditional wave intensity analysis with identification of Windkessel pressures to account for the effect on the pressure waveform of peripheral wave reflections. Using haemodynamic data measured in vivo in the rabbit or generated numerically in models of human compliant vessels, we show that traditional wave intensity analysis identifies the timing, direction and magnitude of the predominant waves that shape aortic pressure and flow waveforms in systole, but fails to identify the effect of peripheral reflections. These reflections persist for several cardiac cycles and make up most of the pressure waveform, especially in diastole and early systole. Ignoring peripheral reflections leads to an erroneous indication of a reflection-free period in early systole and additional error in the estimates of (i) pulse wave velocity at the ascending aorta given by the PU–loop method (9.5% error) and (ii) transit time to a dominant reflection site calculated from the wave intensity profile (27% error). These errors decreased to 1.3% and 10%, respectively, when accounting for peripheral reflections. Using our new analysis, we investigate the effect of vessel compliance and peripheral resistance on wave intensity, peripheral reflections and reflections originating in previous cardiac cycles.
人体动脉网络模型中的脉搏波传播:根据体外测量评估一维粘弹性模拟。
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期刊: CIRCULATION
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