Vaccination strategies to enhance immunity in neonates.
Vaccination strategies to enhance immunity in neonates.
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DOI：
10.1126/science.aaz9447
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发表时间：
2020-05-08
期刊：
影响因子：
--
通讯作者：
Way SS
中科院分区：
文献类型：
--
作者：
Kollmann TR;Marchant A;Way SS
新生儿特别容易受到感染。尽管它们对大多数疫苗有反应，但这种脆弱性还是会发生。然而，目前的疫苗并不针对导致大多数严重新生儿感染的病原体，并且疫苗接种后诱导保护性病原体特异性免疫所需的时间限制了生命最初几天至几周的保护。替代策略包括使用疫苗以病原体不可知的方式广泛刺激新生儿免疫力，或在怀孕期间为妇女接种疫苗，以诱导保护性抗体，这些抗体在其脆弱性窗口内垂直转移给后代。通过整合这些方法，即在垂直转移的母体免疫的掩护下为新生儿接种疫苗，可进一步改善保护。讨论了每一种替代办法的理由和知识差距。
Neonates are particularly susceptible to infection. This vulnerability occurs despite their responsiveness to most vaccines. However, current vaccines do not target the pathogens responsible for most of the severe neonatal infections, and the time it takes to induce protective pathogen-specific immunity after vaccination limits protection in the first days to weeks of life. Alternative strategies include using vaccines to broadly stimulate neonatal immunity in a pathogen-agnostic fashion or vaccinating women during pregnancy to induce protective antibodies that are vertically transferred to offspring within their window of vulnerability. Protection may be further improved by integrating these approaches, namely vaccinating the neonate under the cover of vertically transferred maternal immunity. The rationale for and knowledge gaps related to each of these alternatives are discussed.
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影响因子：
5.1
作者：
ALBRECHT, P;ENNIS, FA;KRUGMAN, S
通讯作者：
KRUGMAN, S
影响因子：
168.9
作者：
Amirthalingam, Gayatri;Andrews, Nick;Ramsay, Mary
通讯作者：
Ramsay, Mary
影响因子：
3.2
作者：
Berendsen, Mike L. T.;Oland, Christian Bjerregard;Aaby, Peter
通讯作者：
Aaby, Peter
DOI：
10.1093/cid/civ617
发表时间：
2015-11-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Lund N;Andersen A;Hansen AS;Jepsen FS;Barbosa A;Biering-Sørensen S;Rodrigues A;Ravn H;Aaby P;Benn CS
通讯作者：
Benn CS
DOI：
10.1038/nri.2017.38
发表时间：
2017-08
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Kinder JM;Stelzer IA;Arck PC;Way SS
通讯作者：
Way SS