Spatio-temporal distribution and agroecological factors associated with canine leptospirosis in Great Britain.
Spatio-temporal distribution and agroecological factors associated with canine leptospirosis in Great Britain.
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DOI：
10.1016/j.prevetmed.2021.105407
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发表时间：
2021-08
影响因子：
2.6
通讯作者：
Stevens KB
中科院分区：
文献类型：
--
作者：
Taylor C;Brodbelt DC;Dobson B;Catchpole B;O'Neill DG;Stevens KB
钩端螺旋体病是一种重要的全球性人畜共患疾病，影响范围广泛的哺乳动物物种。犬钩端螺旋体病爆发已报告后，气象事件，如洪水（如。在巴西和美利坚合众国），这表明一个环境协会，但一直没有这样的研究在英国（GB）。也未报告病例在GB中的分布。本研究的目的是：（1）评估钩端螺旋体病检测提交的时空变化（2）探索农业生态风险因素与GB中不同犬钩端螺旋体病血清群分布之间的关联，以及（3）生成不同血清群的存在概率图。分析的数据包括2009年1月1日至2018年12月31日期间提交给IDEXX实验室进行PCR或MAT钩端螺旋体病检测的实验室资料（n = 3986）。空间和季节扫描统计被用来调查空间和时间聚集的阳性测试，逻辑回归被用来确定显着的农业生态风险因素的阳性测试，和Maxent算法被用来模拟环境生态位的四个血清群。在英格兰西米德兰兹郡（相对风险= 2.16）和10月至1月（相对风险= 1.54）之间，阳性检测结果的风险增加。Logistic回归分析表明，季节和地区与阳性诊断显著相关，秋季阳性检测的几率较高（OR = 1.86 95% CI 1.29−2.69）和冬季（OR = 1.51，95% CI 1.02 - 2.23）以及东部（OR = 2.20，95% CI = 1.31 - 3.71）和西米德兰兹（OR = 2.32，95% CI 1.45 - 3.71）。秋季检测阳性比例的增加以及秋季阳性诊断几率的增加表明GB中犬钩端螺旋体病可能存在季节性模式。在所有生态位模型中，与钩端螺旋体病高发相关的最重要的变量是年平均气温较高。其他变量的重要性和保留率在血清群之间存在差异。总体而言，预测在英格兰南部出现钩端螺旋体病的可能性较高，而在苏格兰和英格兰北方的可能性较低。虽然钩端螺旋体病疫苗的使用提供了对大多数血清群的保护，在这里确定的，一个是不代表在目前许可的疫苗配方，因此钩端螺旋体病应仍然是一个鉴别诊断接种疫苗的狗表现出一致的疾病的临床体征。
Leptospirosis is an important global zoonotic disease that affects a wide range of mammalian species. Canine leptospirosis outbreaks have been reported after metereological events such as flooding (eg. in Brazil and the United States of America) suggesting an environmental association, but there has been no such study in Great Britain (GB). The distribution of cases across GB is also unreported. Objectives of this study were to: (1) assess the spatio-temporal variation of leptospirosis test submissions (2) explore associations between agroecological risk factors and distribution of different canine leptospirosis serogroups in GB, and (3) generate probability of presence maps for the different serogroups. Data analysed comprised laboratory submissions (n = 3986) to IDEXX laboratories between 1st January 2009 and 31st December 2018 for PCR or MAT leptospirosis testing. Spatial and seasonal scan statistics were used to investigate spatial and temporal clustering of positive tests, logistic regression was used to identify significant agroecological risk factors for positive tests, and the Maxent algorithm was used to model the environmental niche of four serogroups. There was an increased risk of a positive test result in the West Midlands of England (relative risk = 2.16) and between October and January (relative risk = 1.54). Logistic regression identified season and region to be significantly associated with a positive diagnosis,with higher odds of a positive test in Autumn (OR = 1.86 95 %CI 1.29−2.69) and Winter (OR = 1.51, 95 %CI 1.02−2.23) and in the East (OR = 2.20, 95 %CI = 1.31−3.71) and West Midlands (OR = 2.32, 95 %CI 1.45−3.71). The increased test-positive proportion in Autumn together with the increased odds of a positive diagnosis in Autumn suggests there may be a seasonal pattern to the canine leptospirosis in GB. The most important variable associated with higher leptospirosis presence in all ecological niche models was higher average annual temperature. The importance and retention of other variables differed between serogroups. Overall, a higher probability of leptospirosis presence was predicted in southern England and a low probability in Scotland and northern England. Although leptospirosis vaccine usage provides protection against the majority of serogroups identified here, one is not represented in the currently licensed vaccine formulations and therefore leptospirosis should remain a differential diagnosis in vaccinated dogs demonstrating consistent clinical signs of the disease.
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影响因子：
2.6
作者：
Francey T;Schweighauser A;Reber A;Schuller S
通讯作者：
Schuller S
微凝集测试（MAT）是否有助于预测巴西钩端螺旋体病的感染血清群？
DOI：
10.1016/j.cimid.2015.12.003
发表时间：
2016-02
期刊：
Comparative immunology, microbiology and infectious diseases
影响因子：
--
作者：
Blanco RM;dos Santos LF;Galloway RL;Romero EC
通讯作者：
Romero EC
影响因子：
3.7
作者：
Dechet, Amy M.;Parsons, Michele;Mintz, Eric D.
通讯作者：
Mintz, Eric D.
影响因子：
3.7
作者：
Aegerter J;Fouracre D;Smith GC
通讯作者：
Smith GC
DOI：
10.4269/ajtmh.2007.76.882
发表时间：
2007-05-01
影响因子：
3.3
作者：
Gaynor, Kate;Katz, Alan R.;Effler, Paul V.
通讯作者：
Effler, Paul V.