Evaluation of changes in the epidemiology of leptospirosis in dogs after introduction of a quadrivalent antileptospiral vaccine in a highly endemic area.
Evaluation of changes in the epidemiology of leptospirosis in dogs after introduction of a quadrivalent antileptospiral vaccine in a highly endemic area.
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DOI：
10.1111/jvim.15947
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发表时间：
2020-11
影响因子：
2.6
通讯作者：
Schuller S
中科院分区：
文献类型：
--
作者：
Francey T;Schweighauser A;Reber A;Schuller S
自2003年以来，在瑞士的狗中观察到澳大利亚钩端螺旋体病血清群的显著增加。2013年，引入了一种新的四价抗钩端螺旋体疫苗（L4），在以前的二价疫苗（L2）的犬瘟和黄疸出血热血清群之外增加了Australis和gripo伤寒血清群。研究L4的引入是否与钩端螺旋体病发病率的降低以及急性肾损伤（AKI）犬被诊断为钩端螺旋体病的几率的降低有关。向转诊医院提交了469只患有AKI的狗，包括269只患有钩端螺旋体病的狗和200只患有其他原因的对照狗。描述性部分：对连续3个时期的疾病发病率进行评估：引入L4之前（PRE, 2011 - 2012）、过渡期（TRANS, 2013 - 2014）和引入L4之后（POST, 2015 - 2017）。分析部分：在一项病例对照研究中，使用多变量逻辑回归研究了与钩端螺旋体病诊断相关的变量，重点是疫苗接种。诊断为钩端螺旋体病（AKI‐L）的犬只数量从56.5例(PRE) /年下降到15.7例(POST) /年，而对照组从16.5例增加到38.0例/年。对照犬（AKI‐nL） L2疫苗接种率降低（100% - 26%），L4疫苗接种率增加（0% - 70%）。接种疫苗的犬被诊断为钩端螺旋体病的优势比为0.11(95%可信区间[CI]， 0.06‐0.22;P <。L4为001)，L2为2.08（0.58‐7.42;P = 0.26）。在瑞士，L4的引入与患钩端螺旋体病和AKI的狗的显著减少有关。使用L4疫苗可显著降低患病几率。
Since 2003, a marked increase in leptospirosis serogroup Australis has been observed in dogs in Switzerland. In 2013, a new quadrivalent antileptospiral vaccine (L4) was introduced, adding serogroups Australis and Grippotyphosa to Canicola and Icterohaemorrhagiae of the previous bivalent vaccines (L2). To examine whether introduction of L4 was associated with decreased incidence of leptospirosis and decreased odds for dogs with acute kidney injury (AKI) to be diagnosed with leptospirosis. Four hundred and sixty‐nine dogs with AKI presented to a referral hospital, including 269 dogs with leptospirosis and 200 controls with other causes. Descriptive section: disease incidence was evaluated for 3 consecutive periods: before (PRE, 2011‐2012), transition (TRANS, 2013‐2014), and after introduction of L4 (POST, 2015‐2017). Analytical section: variables associated with a diagnosis of leptospirosis were investigated in a case‐control study using multivariable logistic regression, and focusing on vaccination. The number of dogs diagnosed with leptospirosis (AKI‐L) decreased from 56.5 (PRE) to 15.7 (POST) cases/year while controls increased from 16.5 to 38.0 cases/year. Control dogs (AKI‐nL) showed a decrease in L2 vaccination (100% to 26%) and an increase in L4 vaccination (0% to 70%). The odds ratio for vaccinated dogs to be diagnosed with leptospirosis was 0.11 (95% confidence interval [CI], 0.06‐0.22; P < .001) for L4 and 2.08 (0.58‐7.42; P = .26) for L2. The introduction of L4 was associated with a marked decrease in dogs with leptospirosis and AKI in Switzerland. Use of the L4 vaccine was associated with significantly decreased odds of disease.
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影响因子：
2.2
作者：
Klaasen, H. L. B. M.;van der Veen, M.;Sutton, D.
通讯作者：
Sutton, D.
影响因子：
3.3
作者：
Sperandei S
通讯作者：
Sperandei S
影响因子：
1.6
作者：
Jull, D. J.;Heath, K. R.
通讯作者：
Heath, K. R.
影响因子：
2.6
作者：
Sykes JE;Hartmann K;Lunn KF;Moore GE;Stoddard RA;Goldstein RE
通讯作者：
Goldstein RE
DOI：
10.20506/rst.37.2.2811
发表时间：
2018-08-01
影响因子：
0.6
作者：
Mueller, T. F.;Freuling, C. M.
通讯作者：
Freuling, C. M.