Mechanism of increased hepatic concentration of carnitine by clofibrate.
Mechanism of increased hepatic concentration of carnitine by clofibrate.
复制标题
氯贝特增加肝脏肉碱浓度的机制。
DOI：
10.1152/ajpendo.1986.251.3.e311
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Adibi,SA
中科院分区：
文献类型：
--
作者：
Paul,HS;Gleditsch,CE;Adibi,SA
我们以前的研究表明，用降血脂药物氯贝特治疗大鼠，大大增加了肝脏中肉毒碱的总浓度（H。S. Paul和S. A. Adibi，J. Clin. Invest. 64：405-412，1979）。在本实验中，我们研究了一些可能的机制来解释这种增加。氯贝特治疗（30 mg/100 g大鼠/天，持续2周）显著增加游离（289 +/- 21 vs. 1，747 +/- 131）和酰基肉毒碱（87 +/- 11 vs. 412 +/- 42）的浓度（nmol/g，平均值+/- SE，6只大鼠）。这些增加不是由于组织之间的肉毒碱重新分配或由于尿排泄减少。鉴于以前的观察，甲状腺激素增加肝脏中的肉毒碱浓度，和氯贝丁酯治疗导致甲状腺功能亢进的状态在肝脏中，我们研究了氯贝丁酯在甲状腺切除大鼠的影响。甲状腺切除大鼠的氯贝特治疗也增加了肝脏中游离（423 +/- 25 vs. 1，460 +/- 123）和酰基肉毒碱（35 +/- 6 vs. 305 +/- 31）的浓度。最后，氯贝特治疗显著增加了三甲基赖氨酸（肉毒碱的前体）的尿排泄（31 +/- 3 vs. 47 +/- 4 nmol/mg肌酐，平均值+/- SE，5只大鼠）。我们的数据表明，氯贝丁酯治疗刺激肝脏合成的肉毒碱，通过增加其前体，三甲基赖氨酸的可用性。氯贝丁酯的这种作用不依赖于甲状腺激素。
Our previous studies have shown that treatment of rats with clofibrate, a hypolipidemic drug, greatly increases the total concentration of carnitine in the liver (H. S. Paul and S. A. Adibi, J. Clin. Invest. 64: 405-412, 1979). In the present experiment we have investigated some possible mechanisms to account for this increase. Clofibrate treatment (30 mg/100 g rat/day for 2 wk) increased significantly the concentration (nmol/g, mean +/- SE, 6 rats) of both free (289 +/- 21 vs. 1,747 +/- 131) and acylcarnitine (87 +/- 11 vs. 412 +/- 42). These increases were not the result of redistribution of carnitine among tissues or due to a decrease in urinary excretion. In view of previous observations that thyroid hormones increase the hepatic concentrations of carnitine, and clofibrate treatment causes a hyperthyroid state in the liver, we investigated the effect of clofibrate in thyroidectomized rats. Clofibrate treatment of thyroidectomized rats also increased the concentration of free (423 +/- 25 vs. 1,460 +/- 123) and acylcarnitine (35 +/- 6 vs. 305 +/- 31) in the liver. Finally, clofibrate treatment significantly increased the urinary excretion of trimethyllysine, a precursor of carnitine (31 +/- 3 vs. 47 +/- 4 nmol/mg creatinine, mean +/- SE, 5 rats). Our data suggest that clofibrate treatment stimulates hepatic synthesis of carnitine by increasing the availability of its precursor, trimethyllysine. This effect of clofibrate is independent of thyroid hormone.
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影响因子：
--
作者：
M. Repka;R. Beck;J. Holmes;E. Birch;D. Chandler;S. Cotter;R. Hertle;R. Kraker;P. Moke;G. Quinn-G
通讯作者：
M. Repka;R. Beck;J. Holmes;E. Birch;D. Chandler;S. Cotter;R. Hertle;R. Kraker;P. Moke;G. Quinn-G
影响因子：
1.6
作者：
Varadharajan, Srinivasa;Hussaindeen, Jameel Rizwana
通讯作者：
Hussaindeen, Jameel Rizwana
影响因子：
4.4
作者：
Fawcett, SL;Wang, YZ;Birch, EE
通讯作者：
Birch, EE
影响因子：
2.8
作者：
R. Achtman;C. S. Green;D. Bavelier
通讯作者：
R. Achtman;C. S. Green;D. Bavelier
根据视觉和动眼神经性能对弱视进行分类。
DOI：
--
发表时间：
1992
期刊：
Transactions of the American Ophthalmological Society
影响因子：
--
作者：
McKee,SP;Schor,CM;Steinman,SB;Wilson,N;Koch,GG;Davis,SM;Hsu-Winges,C;Day,SH;Chan,CL;Movshon,JA
通讯作者：
Movshon,JA