Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs-fMRI study.
Altered functional connectivity of the nucleus tractus solitarii in patients with chronic cough after lung surgery: an rs-fMRI study.
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DOI：
10.1111/1759-7714.15110
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发表时间：
2023-11
期刊：
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
利用静息状态功能磁共振成像（rs - fMRI）探讨肺部手术后慢性咳嗽患者孤独束核（NTS）功能连通性（FC）的改变，以及FC异常与临床评分之间的关系。共纳入22例肺部手术后慢性咳嗽患者和22例健康对照。评估视觉模拟量表（VAS）、汉语版莱斯特咳嗽问卷（LCQ‐MC）和汉密尔顿焦虑评定量表（HAMA）得分，并收集rs‐fMRI数据。以NTS为种子点进行FC分析，计算全脑所有体素的FC值。采用双样本t检验比较两组间FC差异。提取有差异的脑区FC值，并与临床量表评分相关联。与健康对照组相比，肺部手术后慢性咳嗽患者NTS和前扣带皮层（ACC） FC值降低（GRF校正，p‐体素< 0.005，p‐聚类< 0.05），与LCQ‐MC评分呈正相关（r = 0.534, p = 0.011），但与VAS （r = - 0.500, p = 0.018）、HAMA （r = - 0.713, p < 0.001）评分呈负相关。患有ACC的NTS的FC降低可能与咳嗽过敏有关，并可能导致肺部手术后慢性咳嗽患者的焦虑。与健康组相比，慢性咳嗽患者孤独束核（NTS）与前扣带皮层（ACC）之间的功能连通性（FC）降低。使用NTS作为种子点，慢性咳嗽患者的左ACC是全脑FC低于健康人的大脑区域，蓝色代表FC弱。
To explore the altered functional connectivity (FC) of the nucleus tractus solitarii (NTS) in patients with chronic cough after lung surgery using resting‐state functional magnetic resonance imaging (rs‐fMRI), and the association between abnormal FC and clinical scale scores. A total of 22 patients with chronic cough after lung surgery and 22 healthy controls were included. Visual analog scale (VAS), Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ‐MC), and Hamilton anxiety rating scale (HAMA) scores were assessed, and rs‐fMRI data were collected. The FC analysis was performed using the NTS as the seed point, and FC values with all voxels in the whole brain were calculated. A two‐sample t‐test was used to compare FC differences between the two groups. The FC values of brain regions with differences were extracted and correlated with clinical scale scores. In comparison to healthy controls, FC values in the NTS and anterior cingulate cortex(ACC) were reduced in patients with chronic cough after lung surgery (GRF correction, p‐voxel < 0.005, p‐cluster < 0.05) which were positively correlated with LCQ‐MC scores (r = 0.534, p = 0.011), but with VAS (r = −0.500, p = 0.018), HAMA (r = −0.713, p < 0.001) scores were negatively correlated. Reduced FC of the NTS with ACC may be associated with cough hypersensitivity and may contribute to anxiety in patients with chronic cough after lung surgery. Compared with the healthy group, the functional connectivity (FC) between the nucleus tractus solitarii (NTS) and anterior cingulate cortex (ACC) was decreased in patients with chronic cough. Using the NTS as the seed point, the left ACC is the brain region with lower whole‐brain FC in chronic cough patients than in healthy people, and blue represents the FC weakness.
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影响因子：
5.6
作者：
Chaitanya, Ganne;Hampson, Johnson P.;Toth, Emilia;Hupp, Norma J.;Hampson, Jaison S.;Mosher, John C.;Pati, Sandipan;Lhatoo, Samden D.;Lacuey, Nuria
通讯作者：
Lacuey, Nuria
影响因子：
9.6
作者：
Arinze, Johnmary T.;Vinke, Elisabeth J.;Verhamme, Katia M. C.;de Ridder, Maria A. J.;Stricker, Bruno;Ikram, M. K.;Brusselle, Guy;Vernooij, Meike W.
通讯作者：
Vernooij, Meike W.
影响因子：
2.9
作者：
Xie, Ming-ran;Zhu, Yong-fu;Xu, Mei-qing
通讯作者：
Xu, Mei-qing
影响因子：
2.3
作者：
Kotmanova Z;Simera M;Veternik M;Martvon L;Misek J;Jakus J;Shen TY;Musselwhite MN;Pitts T;Bolser DC;Poliacek I
通讯作者：
Poliacek I
长期服用含可待因止咳糖浆的异常程度中心性：一项静息态功能磁共振成像研究。
DOI：
10.1016/j.nicl.2018.06.003
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Hua K;Wang T;Li C;Li S;Ma X;Li C;Li M;Fu S;Yin Y;Wu Y;Liu M;Yu K;Fang J;Wang P;Jiang G
通讯作者：
Jiang G