Chronic Cough-Related Differences in Brain Morphometry in Adults: A Population-Based Study.
Chronic Cough-Related Differences in Brain Morphometry in Adults: A Population-Based Study.
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成人慢性咳嗽相关脑形态测量学差异：一项基于人群的研究。
DOI：
10.1016/j.chest.2023.02.007
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发表时间：
2023-07
期刊：
影响因子：
9.6
通讯作者：
Vernooij, Meike W.
中科院分区：
文献类型：
--
作者：
Arinze, Johnmary T.;Vinke, Elisabeth J.;Verhamme, Katia M. C.;de Ridder, Maria A. J.;Stricker, Bruno;Ikram, M. K.;Brusselle, Guy;Vernooij, Meike W.
咳嗽过敏的个体对咳嗽刺激的中枢神经反应增加，这可能导致中枢咳嗽处理系统出现适应不良的形态变化。患有慢性咳嗽的成年人与没有慢性咳嗽的成年人相比，与咳嗽过敏有关的大脑区域的体积是否不同？ 2009 年至 2014 年间，鹿特丹研究（一项以人群为基础的队列研究）的参与者接受了脑部 MRI 检查，并接受了慢性咳嗽的访谈，慢性咳嗽的定义是每天咳嗽至少 3 个月。使用分区软件对区域脑体积进行量化。根据文献综述，我们确定并研究了先前与慢性咳嗽中的功能性大脑活动改变相关的七个大脑区域。使用多变量回归模型研究了慢性咳嗽与局部脑容量之间的关系。在 3,620 名研究参与者中，有 9.6%（人数 = 349）患有慢性咳嗽（平均年龄为 68.5 ± 9.0 岁；54.6% 为女性）。患有慢性咳嗽的参与者的前扣带皮层体积明显小于没有慢性咳嗽的参与者（平均差，˗126.16 mm3；95% CI，-245.67 至 -6.66；P = .039）。除前扣带皮层外，其他脑区的体积在慢性咳嗽状态下没有显着差异。前扣带皮层的体积差异在左半球（平均差，-88.11 mm3；95% CI，-165.16 至 -11.06；P = .025）和男性参与者中更为明显（平均差，-242.58 mm3；95% CI，-428.60 至 -56.55；P = .011）。患有慢性咳嗽的人的前扣带皮层体积较小，前扣带皮层是参与抑制咳嗽的大脑区域。荷兰国家试验注册中心 (NTR; www.trialregister.nl) 和世界卫生组织的国际临床试验注册平台 (ICTRP; www.who.int/ictrp/network/primary/en/)，联合目录号为 NTR6831。
Individuals with cough hypersensitivity have increased central neural responses to tussive stimuli, which may result in maladaptive morphometric changes in the central cough processing systems. Are the volumes of the brain regions implicated in cough hypersensitivity different in adults with chronic cough compared with adults without chronic cough? Between 2009 and 2014, participants in the Rotterdam Study, a population-based cohort, underwent brain MRI and were interviewed for chronic cough, which was defined as daily coughing for at least 3 months. Regional brain volumes were quantified with the use of parcellation software. Based on literature review, we identified and studied seven brain regions that previously had been associated with altered functional brain activity in chronic cough. The relationship between chronic cough and regional brain volumes was investigated with the use of multivariable regression models. Chronic cough was prevalent in 9.6% (No. = 349) of the 3,620 study participants (mean age, 68.5 ± 9.0 years; 54.6% female). Participants with chronic cough had significantly smaller anterior cingulate cortex volume than participants without chronic cough (mean difference, ˗126.16 mm3; 95% CI, −245.67 to −6.66; P = .039). Except for anterior cingulate cortex, there were no significant difference in the volume of other brain regions based on chronic cough status. The volume difference in the anterior cingulate cortex was more pronounced in the left hemisphere (mean difference, −88.11 mm3; 95% CI, −165.16 to −11.06; P = .025) and in male participants (mean difference, −242.58 mm3; 95% CI, −428.60 to −56.55; P = .011). Individuals with chronic cough have a smaller volume of the anterior cingulate cortex, which is a brain region involved in cough suppression. The Netherlands National Trial Registry (NTR; www.trialregister.nl) and the World Health Organization’s International Clinical Trials Registry Platform (ICTRP; www.who.int/ictrp/network/primary/en/) under the joint catalogue number NTR6831.
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影响因子：
3.2
作者：
Ryan NM;Vertigan AE;Birring SS
通讯作者：
Birring SS
影响因子：
24.3
作者：
Morice, Alyn H.;Millqvist, Eva;Smith, Jaclyn A.
通讯作者：
Smith, Jaclyn A.
影响因子：
2.9
作者：
Mann SL;Hazlett EA;Byne W;Hof PR;Buchsbaum MS;Cohen BH;Goldstein KE;Haznedar MM;Mitsis EM;Siever LJ;Chu KW
通讯作者：
Chu KW
影响因子：
--
作者：
Scahill, RI;Frost, C;Fox, NC
通讯作者：
Fox, NC
影响因子：
2.9
作者：
Hull JH;Langerman H;Ul-Haq Z;Kamalati T;Lucas A;Levy ML
通讯作者：
Levy ML