Fire and Brimstone: Molecular Interactions between Sulfur and Glucosinolate Biosynthesis in Model and Crop Brassicaceae.
Fire and Brimstone: Molecular Interactions between Sulfur and Glucosinolate Biosynthesis in Model and Crop Brassicaceae.
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DOI：
10.3389/fpls.2016.01735
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发表时间：
2016
影响因子：
5.6
通讯作者：
King GJ
中科院分区：
文献类型：
--
作者：
Borpatragohain P;Rose TJ;King GJ
硫代葡萄糖苷（GSL）是植物次生代谢产物中研究最广泛的一类，具有广泛的生物活性。它们的独特性质也影响牲畜和人类健康，并已被用于食品和其他最终用途。由于GSL富含硫（S），有许多证据表明，植物S状态在决定植物GSL含量方面起着关键作用。然而，仍然有必要建立一个详细的知识的分布和再动员的S和GSL的整个发展的芸苔属作物，并代表这方面的主要和次要的源和汇。芸苔属植物基因组复杂性的增加、基因的重复和分化，以及作物发育过程中的个体发育可塑性，似乎对S和GSL的调控有显著影响。在这里，我们回顾了目前的理解无机S（硫酸盐）同化成有机S的形式，包括GSL和它们的前体，无机和有机S形式的细胞内和器官间运输，以及GSL在特定组织中的积累。我们目前这方面的重叠源和汇，运输过程，信号分子及其相关的分子相互作用。我们的分析建立在最近的见解硫酸盐吸收和运输的分子调控不同的转运蛋白，转录因子和miRNA，以及这些可能发挥的作用，在GSL生物合成。我们开发了一个临时模型，描述了在作物育种计划中可能针对的关键过程，重点是修改GSL含量。
Glucosinolates (GSLs) represent one of the most widely studied classes of plant secondary metabolite, and have a wide range of biological activities. Their unique properties also affect livestock and human health, and have been harnessed for food and other end-uses. Since GSLs are sulfur (S)-rich there are many lines of evidence suggesting that plant S status plays a key role in determining plant GSL content. However, there is still a need to establish a detailed knowledge of the distribution and remobilization of S and GSLs throughout the development of Brassica crops, and to represent this in terms of primary and secondary sources and sinks. The increased genome complexity, gene duplication and divergence within brassicas, together with their ontogenetic plasticity during crop development, appear to have a marked effect on the regulation of S and GSLs. Here, we review the current understanding of inorganic S (sulfate) assimilation into organic S forms, including GSLs and their precursors, the intracellular and inter-organ transport of inorganic and organic S forms, and the accumulation of GSLs in specific tissues. We present this in the context of overlapping sources and sinks, transport processes, signaling molecules and their associated molecular interactions. Our analysis builds on recent insights into the molecular regulation of sulfate uptake and transport by different transporters, transcription factors and miRNAs, and the role that these may play in GSL biosynthesis. We develop a provisional model describing the key processes that could be targeted in crop breeding programs focused on modifying GSL content.
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影响因子：
11.6
作者：
Andersen, Tonni Grube;Nour-Eldin, Hussam Hassan;Halkier, Barbara Ann
通讯作者：
Halkier, Barbara Ann
影响因子：
13.8
作者：
Augustine, Rehna;Mukhopadhyay, Arundhati;Bisht, Naveen C.
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Bisht, Naveen C.
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Sorensen, Hilmer
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5.8
作者：
Bonnet, E;Wuyts, J;Van de Peer, Y
通讯作者：
Van de Peer, Y
影响因子：
6.9
作者：
Augustine R;Majee M;Gershenzon J;Bisht NC
通讯作者：
Bisht NC