Child transmission of SARS-CoV-2: a systematic review and meta-analysis.
Child transmission of SARS-CoV-2: a systematic review and meta-analysis.
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DOI：
10.1186/s12887-022-03175-8
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发表时间：
2022-04-02
期刊：
影响因子：
2.4
通讯作者：
Sadarangani M
中科院分区：
文献类型：
--
作者：
Silverberg SL;Zhang BY;Li SNJ;Burgert C;Shulha HP;Kitchin V;Sauvé L;Sadarangani M
了解儿童在COVID-19传播中的作用对学校和儿童保育政策以及疫苗接种活动的适当针对性具有重要意义。本系统评价的目的是确定儿童在SARS-CoV-2传播给其他儿童和成人中的作用。电子检索MEDLINE、EMBASE、CINAHL、科克伦对照试验中心注册中心和Web of Science，查找2021年3月31日之前发表的文章。确定了儿童对儿童和儿童对成人传播的研究，并量化了学校、家庭和其他聚集儿科环境中儿童和成人的指数发病率和继发性发病率。纳入了所有描述证实的儿童传播SARS-CoV-2的文章。遵循PRISMA数据提取指南，每个步骤由两名评审员进行。识别的6110篇文章中有40篇符合纳入标准。总的来说，每例原发性索引病例有0.8例继发性病例，已知接触者的继发性发病率为8.4%。成人接触者的二次发病率为26.4%，而儿童接触者的二次发病率为5.7%。儿科索引病例接触者感染继发病例的汇总估计值为0.10（95% CI 0.03-0.25）。儿童传播COVID-19的比率低于成人。家庭中的成年人被受感染儿童传染的风险最高，高于其他环境中的成年人或儿童。在线版本包含补充材料，可通过10.1186/s12887-022-03175-8获得。
Understanding of the role of children in COVID-19 transmission has significant implications for school and childcare policies, as well as appropriate targeting of vaccine campaigns. The objective of this systematic review was to identify the role of children in SARS-CoV-2 transmission to other children and adults. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and Web of Science were electronically searched for articles published before March 31, 2021. Studies of child-to-child and child-to-adult transmission and quantified the incidence of index and resulting secondary attack rates of children and adults in schools, households, and other congregate pediatric settings were identified. All articles describing confirmed transmission of SARS-CoV-2 from a child were included. PRISMA guidelines for data abstraction were followed, with each step conducted by two reviewers. 40 of 6110 articles identified met inclusion criteria. Overall, there were 0.8 secondary cases per primary index case, with a secondary attack rate of 8.4% among known contacts. The secondary attack rate was 26.4% among adult contacts versus 5.7% amongst child contacts. The pooled estimate of a contact of a pediatric index case being infected as secondary case was 0.10 (95% CI 0.03-0.25). Children transmit COVID-19 at a lower rate to children than to adults. Household adults are at highest risk of transmission from an infected child, more so than adults or children in other settings. The online version contains supplementary material available at 10.1186/s12887-022-03175-8.
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DOI：
10.2807/1560-7917.es.2020.25.36.2001587
发表时间：
2020-09
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Ehrhardt J;Ekinci A;Krehl H;Meincke M;Finci I;Klein J;Geisel B;Wagner-Wiening C;Eichner M;Brockmann SO
通讯作者：
Brockmann SO
影响因子：
33.9
作者：
Blaisdell, Laura L.;Cohn, Wendy;Vergales, Jeffrey E.
通讯作者：
Vergales, Jeffrey E.
影响因子：
19
作者：
Heavey, Laura;Casey, Geraldine;McDarby, Geraldine
通讯作者：
McDarby, Geraldine
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
16.6
作者：
Bi Q;Lessler J;Eckerle I;Lauer SA;Kaiser L;Vuilleumier N;Cummings DAT;Flahault A;Petrovic D;Guessous I;Stringhini S;Azman AS;SEROCoV-POP Study Group
通讯作者：
SEROCoV-POP Study Group