Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases.
Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases.
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DOI：
10.1177/0300985821999328
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发表时间：
2021-05
影响因子：
2.4
通讯作者：
de Bruin A
中科院分区：
文献类型：
--
作者：
Bongiovanni L;Andriessen A;Wauben MHM;Nolte-'t Hoen ENM;de Bruin A
细胞外囊泡（EVs）的尺寸范围从30到1000纳米不等，是能够运输生物活性分子的最小细胞成分之一。它们介导细胞间通讯，在维持组织稳态和多种疾病的发病机制中发挥重要作用。特别是，ev积极促进癌症的发生和发展，并且对其在转移性生态位的产生中的作用有了新的认识。这一事实是最近EV研究呈指数增长的基础，这提高了我们对它们在疾病中的特定作用及其在诊断和治疗中的潜在应用的理解。电动汽车及其生物分子货物反映了患病供体细胞的状态，可以在体液中检测到，并作为癌症和其他疾病的生物标志物。在兽医领域发表的关于电动汽车的研究相对较少。本文综述了EVs的特征和生物学特性，以及EVs的研究进展，包括分离和分析技术，并讨论了如何在兽医病理学领域研究和利用病变组织释放的EVs。独特的是，本文强调了病理学家对EV研究领域的重要贡献：病理学家可以帮助EV科学家研究和确认EV及其分子货物在病变组织中的作用，以及作为液体活检中的生物标志物。
With a size range from 30 to 1000 nm, extracellular vesicles (EVs) are one of the smallest cell components able to transport biologically active molecules. They mediate intercellular communications and play a fundamental role in the maintenance of tissue homeostasis and pathogenesis in several types of diseases. In particular, EVs actively contribute to cancer initiation and progression, and there is emerging understanding of their role in creation of the metastatic niche. This fact underlies the recent exponential growth in EV research, which has improved our understanding of their specific roles in disease and their potential applications in diagnosis and therapy. EVs and their biomolecular cargo reflect the state of the diseased donor cells, and can be detected in body fluids and exploited as biomarkers in cancer and other diseases. Relatively few studies have been published on EVs in the veterinary field. This review provides an overview of the features and biology of EVs as well as recent developments in EV research including techniques for isolation and analysis, and will address the way in which the EVs released by diseased tissues can be studied and exploited in the field of veterinary pathology. Uniquely, this review emphasizes the important contribution that pathologists can make to the field of EV research: pathologists can help EV scientists in studying and confirming the role of EVs and their molecular cargo in diseased tissues and as biomarkers in liquid biopsies.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
影响因子：
4.8
作者：
Bakhti, Mostafa;Winter, Christine;Simons, Mikael
通讯作者：
Simons, Mikael
影响因子：
2.2
作者：
Boere, J.;van de Lest, C. H. A.;van Weeren, P. R.
通讯作者：
van Weeren, P. R.
影响因子：
4.6
作者：
Almughlliq, Fatema B.;Koh, Yong Q.;Mitchell, Murray D.
通讯作者：
Mitchell, Murray D.
影响因子：
--
作者：
Bae S;Brumbaugh J;Bonavida B
通讯作者：
Bonavida B