A Longitudinal Analysis of the Association Between Long-Term Exposure to Air Pollution and Cognitive Function Among Adults Aged 45 and Older in China.
A Longitudinal Analysis of the Association Between Long-Term Exposure to Air Pollution and Cognitive Function Among Adults Aged 45 and Older in China.
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DOI：
10.1093/geronb/gbac162
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发表时间：
2023-03-04
影响因子：
6.2
通讯作者：
Keenan, Katherine
中科院分区：
文献类型：
--
作者：
Hu, Kai;Hale, Jo Mhairi;Kulu, Hill;Liu, Yang;Keenan, Katherine
有证据表明，长期暴露于空气污染的细颗粒物（PM2.5）与认知障碍的风险较高有关，尤其是在老年人中。本研究探讨了PM2.5暴露与中国老龄化人口认知功能之间的关系。我们使用了来自中国健康与退休纵向研究（2011-2015）的纵向数据，并将其与来自遥感卫星数据的PM2.5历史浓度（2000-2015）联系起来。使用生长曲线模型来估计PM2.5暴露（以强度、持续时间和强度与累积暴露持续时间的联合变量测量）与认知功能之间的关系。与最低暴露组相比，暴露于PM2.5浓度为35 ~ 50 μg/m3的第二组认知功能较差，但PM2.5浓度越高认知功能越好，呈u型关系。在PM2.5持续时间的完全调整模型中也可以看到类似的模式：第二组（13-60个月）的认知功能比第一组（0-12个月）差，但在持续时间较长的组中，系数不显著。PM2.5强度与持续时间的联合分析表明，持续时间对认知功能的影响可能比强度更大。然而，我们没有发现PM2.5暴露与认知能力下降速度之间存在统计学上显著的关联。我们的研究结果好坏参半，表明某些类别的PM2.5暴露时间越长越高，认知功能越差，但这种暴露不会加速认知能力下降。然而，要将PM2.5暴露与个人背景特征，特别是与认知功能和城市生活共同相关的背景特征区分开来，还需要做更多的工作。
Evidence suggests long-term exposure to fine particulate matter air pollution (PM2.5) is associated with a higher risk of cognitive impairment, especially among older adults. This study examines the relationship between PM2.5 exposure and cognitive function in China’s aging population. We used longitudinal data from the China Health and Retirement Longitudinal Study (2011–2015) linked with historical PM2.5 concentrations (2000–2015) from remotely sensed satellite data. Growth curve models were applied to estimate associations between PM2.5 exposure (measured in intensity, duration, and a joint variable of intensity with duration for cumulative exposure) and cognitive function. Relative to the lowest exposure group, exposure in the second group of PM2.5 intensity (35–50 μg/m3) is associated with poorer cognitive function, but higher levels of PM2.5 appear to be associated with better cognitive function, indicating a U-shaped association. Similar patterns are seen for fully adjusted models of PM2.5 duration: the second group (13–60 months) is associated with worse cognitive function than the first group (0–12 months), but coefficients are nonsignificant in longer duration groups. Joint analysis of PM2.5 intensity with duration suggests that duration may play a more detrimental role in cognitive function than intensity. However, we do not find a statistically significant association between PM2.5 exposure and the rate of cognitive decline. Our findings are mixed and suggest that some categories of higher and longer exposure to PM2.5 are associated with poorer cognitive function, while that exposures do not hasten cognitive decline. However, more work is necessary to disentangle PM2.5 exposure from individuals’ background characteristics, particularly those jointly associated with cognitive function and urban living.
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DOI：
10.1016/j.socscimed.2016.11.019
发表时间：
2017-01
期刊：
Social science & medicine (1982)
影响因子：
--
作者：
Ailshire J;Karraker A;Clarke P
通讯作者：
Clarke P
影响因子：
5
作者：
Ailshire, Jennifer A.;Crimmins, Eileen M.
通讯作者：
Crimmins, Eileen M.
影响因子：
2.2
作者：
Kesavayuth, Dusanee;Liang, Yufang;Zikos, Vasileios
通讯作者：
Zikos, Vasileios
中期婚姻状况与后来生活的认知功能之间的关联：基于人群的队列研究。
DOI：
10.1136/bmj.b2462
发表时间：
2009-07-02
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Håkansson K;Rovio S;Helkala EL;Vilska AR;Winblad B;Soininen H;Nissinen A;Mohammed AH;Kivipelto M
通讯作者：
Kivipelto M
影响因子：
15.9
作者：
Block, Michelle L.;Calderon-Garciduenas, Lilian
通讯作者：
Calderon-Garciduenas, Lilian