Sensational placodes: neurogenesis in the otic and olfactory systems.
Sensational placodes: neurogenesis in the otic and olfactory systems.
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DOI：
10.1016/j.ydbio.2014.01.023
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Whitfield, Tanya T.
中科院分区：
文献类型：
--
作者：
Maier, Esther C.;Saxena, Ankur;Alsina, Berta;Bronner, Marianne E.;Whitfield, Tanya T.
对于耳朵中感觉细胞复杂的形态发生布局和鼻子中感觉神经元优雅的放射状排列，需要许多信号分子和遗传决定因素共同产生这些专门的神经元群体，帮助我们与环境联系起来。在这篇综述中，我们概述了许多在耳和嗅觉神经元的分化及其整合到其非神经元的支持结构中发挥重要作用的蛋白质和途径。在这两种情况下，众所周知的信号通路与区域特异性因素一起将增厚的外胚层基板转化为含有许多不同神经元亚型的复杂感觉器官。嗅觉和耳基板，结合迁移神经嵴干细胞，产生高度专业化的神经元细胞亚型，感觉声音，位置和空间运动，气味和信息素在我们的生活。耳板和嗅板产生具有多种细胞类型的复杂器官。在耳板和嗅板中早期就建立了前神经源性结构域。神经嵴细胞主要对耳和鼻中的神经胶质细胞起作用。耳和嗅神经发生受内外因素的调控。耳朵和鼻子中的感觉细胞在再生潜力方面有所不同。
For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives. Otic and olfactory placodes generate complex organs with a variety of cell types. An anterior neurogenic domain is established early in otic and olfactory placodes. Neural crest cells contribute primarily to glial cells in the ear and nose. Otic and olfactory neurogenesis is regulated by extrinsic and intrinsic factors. Sensory cells in the ear and nose differ in their regenerative potential.
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影响因子：
3.7
作者：
Aburto MR;Magariños M;Leon Y;Varela-Nieto I;Sanchez-Calderon H
通讯作者：
Sanchez-Calderon H
影响因子：
11.8
作者：
Ahmed, Mohi;Wong, Elaine Y. M.;Sun, Jianbo;Xu, Jinshu;Wang, Feng;Xu, Pin-Xian
通讯作者：
Xu, Pin-Xian
影响因子：
4.6
作者：
Ahuja, Gaurav;Ivandic, Ivan;Saltuerk, Mehmet;Oka, Yuichiro;Nadler, Walter;Korsching, Sigrun I.
通讯作者：
Korsching, Sigrun I.
DOI：
10.1073/pnas.97.22.11722
发表时间：
2000-10-24
影响因子：
11.1
作者：
Baird, RA;Burton, MD;Naeger, RA
通讯作者：
Naeger, RA
影响因子：
2.8
作者：
Avallone, B;Porritiello, M;Marmo, F
通讯作者：
Marmo, F