Neuropsychiatric symptoms in Parkinson's disease.

Neuropsychiatric symptoms in Parkinson's disease.
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DOI:
10.1002/mds.22589
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发表时间:
2009-11-15
期刊:
影响因子:
8.6
通讯作者:
Schrag, Anette
Schrag, Anette
中科院分区:
医学1区
文献类型:
--
作者:
Aarsland, Dag;Marsh, Laura;Schrag, Anette

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神经精神症状在帕金森病中很常见,即使在最早期,对生活质量和日常功能有重要影响,与护理人员负担增加和入住疗养院的风险增加有关。除认知障碍外,还报告了广泛的神经精神症状。在本文中,流行病学,临床过程中,诊断和管理的一些最常见的神经精神症状的PD进行了讨论:抑郁,焦虑,冷漠,疲劳和精神病性症状。虽然我们对这些症状的流行和病程了解很多,但如何管理这些症状的经验证据充其量是有限的。因此,迫切需要对这些症状的药理学和非药理学管理进行系统研究。
Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages, and have important consequences for quality of life and daily functioning, are associated with increased carer burden and increased risk for nursing home admission. In addition to cognitive impairment, a wide range of neuropsychiatric symptoms have been reported. In this paper, the epidemiology, clinical course, diagnosis, and management of some of the most common neuropsychiatric symptoms in PD are discussed: depression, anxiety, apathy, fatigue and psychotic symptoms. Although much is known regarding the prevalence and course of these symptoms, the empirical evidence for how to manage these symptoms is limited at best. There is thus an urgent need for systematic studies for the pharmacological and non-pharmacological management of these symptoms.
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