Corneal lymphangiogenesis as a potential target in dry eye disease - a systematic review.
Corneal lymphangiogenesis as a potential target in dry eye disease - a systematic review.
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角膜淋巴管生成作为干眼病的潜在靶点——一项系统综述
DOI：
10.1016/j.survophthal.2021.03.007
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发表时间：
2021-11
影响因子：
5.1
通讯作者：
Azar, Dimitri T.
中科院分区：
文献类型：
--
作者：
Chennakesavalu, Mohansrinivas;Somala, Sri Raghurama R.;Dommaraju, Sunil R.;Peesapati, Meghna Priyanka;Guo, Kai;Rosenblatt, Mark I.;Chang, Jin-Hong;Azar, Dimitri T.
干眼病(DED)是一种常见的眼表疾病，会导致严重的不适、视力障碍和疼痛等症状。随着最近的研究进展，DED已被认为是一种由各种内部和环境因素引发的慢性自发性炎症状态。DED被证明是由于天然免疫系统和获得性免疫系统的激活而产生的，导致角膜上皮和泪腺功能障碍。虽然角膜通常是无血管的，因此具有血管生成和淋巴管生成特权，但各种DED模型显示局部淋巴结中有激活的角膜抗原提呈细胞，提示DED形成了新的角膜淋巴管。最近可靠的淋巴细胞表面标记物的出现，如LYVE-1，使研究淋巴管生成成为可能。因此，在过去的十年里，已经发表了许多研究，讨论淋巴管生成在DED病理中的作用。我们系统地回顾文献，以确定和评估关于DED的角膜淋巴管生成数据的研究。有相当多的证据支持角膜淋巴管生成是DED发病的中心介质。这些发现表明，抗淋巴管生成治疗策略可能是治疗DED的一个可行的选择，这一结论得到了研究DED抗淋巴管生成方式的有限临床试验的支持。
Dry eye disease (DED) is a common ocular surface condition causing symptoms of significant discomfort, visual disturbance, and pain. With recent advancements, DED has become recognized as a chronic self-perpetuating inflammatory condition triggered by various internal and environmental factors. DED has been shown to arise from the activation of both the innate and adaptive immune systems, leading to corneal epithelium and lacrimal gland dysfunction. While the cornea is normally avascular and thus imbued with angiogenic and lymphangiogenic privilege, various DED models have revealed activated corneal antigen-presenting cells in regional lymph nodes, suggesting the formation of new corneal lymphatic vessels in DED. The recent availability of reliable lymphatic cell surface markers such as LYVE-1 has made it possible to study lymphangiogenesis. Accordingly, numerous studies have been published within the last decade discussing the role of lymphangiogenesis in DED pathology. We systematically review the literature to identify and evaluate studies presenting data on corneal lymphangiogenesis in DED. There is considerable evidence supporting corneal lymphangiogenesis as a central mediator of DED pathogenesis. These findings suggest that anti-lymphangiogenic therapeutic strategies may be a viable option for the treatment of DED, a conclusion supported by the limited number of reported clinical trials examining anti-lymphangiogenic modalities in DED.
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影响因子：
3.7
作者：
Contreras-Ruiz L;Masli S
通讯作者：
Masli S
DOI：
10.1073/pnas.0506112103
发表时间：
2006-07-25
影响因子：
11.1
作者：
Cursiefen, Claus;Chen, Lu;Dana, Reza
通讯作者：
Dana, Reza
影响因子：
1.9
作者：
Conrady CD;Joos ZP;Patel BC
通讯作者：
Patel BC
影响因子：
1.6
作者：
Chen, Di;Zhang, Shunhua;Zhao, Jialiang
通讯作者：
Zhao, Jialiang
DOI：
10.1073/pnas.95.2.548
发表时间：
1998-01-20
影响因子：
11.1
作者：
Achen, MG;Jeltsch, M;Stacker, SA
通讯作者：
Stacker, SA