Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.
Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury.
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氧雄龙与烧伤后异位骨化可能关联的调查。
DOI：
10.1093/jbcr/irz063
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Schulz,Joh
中科院分区：
文献类型：
--
作者：
Thorpe,CatherineR;UcerOzgurel,Serra;Simko,LauraC;Goldstein,Richard;Grant,GabrielleG;Pagani,Chase;Hwang,Charles;Vasquez,Kaetlin;Sorkin,Michael;Vaishampayan,Anita;Goverman,Jeremy;Sheridan,RobertL;Friedstat,Jonathan;Schulz,Joh
氧甲氢龙是一种睾酮类似物，用于抵消烧伤的分解代谢作用。最近的动物研究表明，激素可能与烧伤后异位骨化（HO）的发展。这项工作探讨氧雄龙管理和HO开发通过探索历史临床数据桥接氧雄龙引入临床实践。此外，我们研究氧雄龙管理和HO在烧伤/创伤相关HO的标准化小鼠模型之间的关联。选择2000年至2014年期间入院的急性烧伤成人，存活至出院，HO风险因子为7或更高，从单个烧伤中心进行分析。记录氧甲氢龙给药、临床和人口统计学数据以及肘关节HO，并进行Logistic回归分析。在小鼠模型中检查氧雄龙与HO的关联。在烧伤/腱切开术后向小鼠施用氧雄龙或载体对照，以检查氧雄龙对HO的任何潜在作用，并通过Student t检验进行分析。接受氧甲氢龙的受试者肘HO的发病率高于未接受氧甲氢龙的受试者。然而，当控制氧甲氢龙管理，氧甲氢龙持续时间，烧伤后氧甲氢龙开始日，HO风险评分类别，年龄，性别，种族，烧伤面积，和受伤的年份，两个人群之间的肘部HO率没有显着差异。与该综述一致，在小鼠模型中，虽然氧雄龙组有发展更大体积HO的趋势，但这并没有达到统计学显著性。
Oxandrolone, a testosterone analog, is used to counteract the catabolic effects of burn injury. Recent animal studies suggest a possible hormonal association with heterotopic ossification (HO) development postburn. This work examines oxandrolone administration and HO development by exploring historical clinical data bridging the introduction of oxandrolone into clinical practice. Additionally, we examine associations between oxandrolone administration and HO in a standardized mouse model of burn/trauma-related HO. Acutely burned adults admitted between 2000 and 2014, survived through discharge, and had a HO risk factor of 7 or higher were selected for analysis from a single burn center. Oxandrolone administration, clinical and demographic data, and elbow HO were recorded and were analyzed with logistic regression. Associations of oxandrolone with HO were examined in a mouse model. Mice were administered oxandrolone or vehicle control following burn/tenotomy to examine any potential effect of oxandrolone on HO and were analyzed by Student’sttest. Subjects who received oxandrolone had a higher incidence of elbow HO than those that did not receive oxandrolone. However, when controlling for oxandrolone administration, oxandrolone duration, postburn day oxandrolone initiation, HO risk score category, age, sex, race, burn size, and year of injury, there was no significant difference between rates of elbow HO between the two populations. In agreement with the review, in the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance.
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DOI：
10.1001/archsurg.1996.01430230068012
发表时间：
1996
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
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作者：
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影响因子：
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R. Holavanahalli;P. Helm;I. Parry;C. Dolezal;D. Greenhalgh
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