Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)-rationale and protocol for a prospective multicentre observational study.
Development of cognition decline in non-acute symptomatic patients with cerebral small vessel disease: Non-Acute Symptomatic Cerebral Ischemia Registration study (NASCIR)-rationale and protocol for a prospective multicentre observational study.
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非急性症状性脑小血管疾病患者认知能力下降的发展：非急性症状性脑缺血登记研究 (NASCIR) — 前瞻性多中心观察性研究的基本原理和方案
DOI：
10.1136/bmjopen-2021-050294
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发表时间：
2022-02-22
期刊：
影响因子：
2.9
通讯作者：
Liu M
中科院分区：
文献类型：
--
作者：
Zhang S;Wang Z;Liu P;Tuo Q;Cheng Y;Xu M;Wu Q;Lei P;Dai L;Kwapong WR;Tan M;Liu M
简介 不明原因引起的头痛、头晕和记忆丧失是老年人群中最常见的非急性缺血症状，这些症状通常与脑小血管病（CSVD）影像学标志物相关；然而，没有足够的证据表明它们与认知能力下降的关系。本研究旨在探讨无症状缺血症状性认知下降患者的危险因素、临床病程、脑部和视网膜影像学变化、蛋白质组学特征。方法与分析 非急性症状性脑缺血登记研究是一项多中心、基于登记的前瞻性观察研究，旨在调查非急性症状性脑缺血患者的认知能力下降情况。我们将从中国四家三级医院招募500名非急性缺血症状患者。在本研究中，非急性缺血症状将被定义为头痛、头晕和记忆丧失。 50岁以上患有头痛、头晕或记忆丧失的患者将被包括在内。招募后将收集临床特征、认知评估、大脑和视网膜成像数据以及血液样本。患者将在招募后 1、2、3、4、5 年通过结构化电话访谈进行随访。这项研究将提高我们对非急性缺血症状患者认知能力下降的发展和影响认知结果的因素的认识，最终阐明这些患者认知能力下降的潜在途径和机制，并有助于优化其预防和治疗的个体化干预措施。伦理与传播获得四川大学华西医院生物医学研究伦理委员会批准（审字号：2016（335））。我们将在中风和神经病学领域的国内和国际会议以及同行评审期刊上展示我们的研究结果。试验注册号 ChiCTR-COC-17013056。
Introduction Headaches, dizziness and memory loss of unspecific causes are the most common non-acute ischemia symptoms in the ageing population, which are often associated with cerebral small vessel disease (CSVD) imaging markers; however, there is insufficient evidence concerning their association with the development of cognitive decline. This study aims to investigate risk factors, clinical course, cerebral and retinal imaging changes, proteomics features of non-symptomatic ischaemia symptomatic patients with cognitive decline. Methods and analysis The Non-Acute Symptomatic Cerebral Ischemia Registration study is a multicentre, registry-based, prospective observational study, is designed to investigate the cognitive decline in non-acute ischaemia symptomatic patients. We will recruit 500 non-acute ischaemia symptomatic patients from four tertiary hospitals in China. For this study, non-acute ischaemia symptoms will be defined as headaches, dizziness and memory loss. Patients with headaches, dizziness or memory loss over 50 years of age will be included. Clinical features, cognitive assessment, cerebral and retinal imaging data, and a blood sample will be collected after recruitment. Patients will be followed up by structured telephone interviews at 1, 2, 3, 4, 5 years after recruitment. This study will improve our knowledge of the development of cognitive decline in non-acute ischaemia symptomatic patients and factors affecting the cognitive outcomes, which will eventually elucidate underlying pathways and mechanisms of cognitive decline in these patients and facilitate the optimisation of individualised interventions for its prevention and treatment. Ethics and dissemination Ethics approval is obtained from The Biomedical Research Ethics Committee of West China Hospital, Sichuan University (Reference No. 2016 (335)). We will present our findings at national and international conferences and peer-reviewed journals in stroke and neurology. Trial registration number ChiCTR-COC-17013056.
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