Changes in brown adipose tissue in boys and girls during childhood and puberty.
Changes in brown adipose tissue in boys and girls during childhood and puberty.
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DOI：
10.1016/j.jpeds.2011.09.035
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发表时间：
2012-04
影响因子：
5.1
通讯作者：
Hu, Houchun H.
中科院分区：
文献类型：
--
作者：
Gilsanz, Vicente;Smith, Michelle L.;Goodarzian, Fariba;Kim, Mimi;Wren, Tishya A. L.;Hu, Houchun H.
描述男孩和女孩青春期棕色脂肪组织 (BAT) 的变化。我们检查了接受正电子发射断层扫描/计算机断层扫描 (PET/CT) 研究的儿科患者在不同性发育阶段的 BAT 患病率和数量。在 73 名患者中，43 名 (59%) 的 PET/CT 上显示了 BAT。在青春期前（Tanner 1 期）儿童的 PET/CT 研究中，可视化 BAT 显着低于青春期（Tanner 2-5 期）受试者（15% 与 75%）。 BAT 体积值在青春期也有所增加，但在青春期最后两个阶段（Tanner 4 或 5 期）增加的幅度明显大于性发育早期阶段（Tanner 1、2 和 3 期）（男孩：499±246 vs. 50±36，p <0.0001，女孩：286±139 vs. 36±29，p = 0.024）。男孩 BAT 体积的变化也显着大于女孩（p = 0.004），并且与肌肉体积密切相关（男孩和女孩的 r's = 0.52、0.64，p 值均<0.01）。在青春期，棕色脂肪的描述和体积会增加。与性成熟相关的代谢和激素事件可能是青春期棕色脂肪快速增加的原因。
To characterize the changes in brown adipose tissue (BAT) during puberty in boys and girls. We examined the prevalence and the volume of BAT at different stages of sexual development in pediatric patients who underwent positron emission tomography/computer tomography (PET/CT) studies. Of the 73 patients, 43 (59%) had BAT depicted on PET/CT. Visualized BAT was significantly less prevalent in PET/CT studies of pre-pubertal (Tanner stage 1) children than pubertal (Tanner stages 2-5) subjects (15% vs. 75%). Values for the volume of BAT also increased during puberty, but the magnitude of the increase was substantially greater during the final two stages of puberty (Tanner stage 4 or 5) than in earlier stages of sexual development (Tanner stages 1, 2, and 3) (Boys: 499±246 vs. 50±36, p <0.0001, Girls: 286±139 vs. 36±29, p = 0.024). Changes in BAT volume were also significantly greater in boys than in girls (p = 0.004) and were closely related to muscle volume (r’s = 0.52, 0.64 and both p’s<0.01, for boys and girls, respectively). The depiction and the volume of brown fat increase during puberty. Metabolic and hormonal events related to the achievement of sexual maturity are likely responsible for the rapid increase in brown fat that occurs during puberty.
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影响因子：
4.4
作者：
Hu, Houchun H.;Smith, Daniel L., Jr.;Nayak, Krishna S.;Goran, Michael I.;Nagy, Tim R.
通讯作者：
Nagy, Tim R.
影响因子：
3.1
作者：
Garcia, CA;Van Nostrand, D;Majd, M
通讯作者：
Majd, M
DOI：
10.1007/s00259-006-0253-9
发表时间：
2007-05-01
影响因子：
9.1
作者：
Bar-Sever, Zvi;Keidar, Zohar;Israel, Ora
通讯作者：
Israel, Ora
影响因子：
2.3
作者：
Gelfand, MJ;O'Hara, SM;MacLean, JR
通讯作者：
MacLean, JR
功能性棕色脂肪组织与儿童和青少年的肌肉体积有关。
影响因子：
5.1
作者：
Gilsanz, Vicente;Chung, Sandra A.;Jackson, Hollie;Dorey, Frederick J.;Hu, Houchun H.
通讯作者：
Hu, Houchun H.