Photochemically Immobilized 4-Methylbenzoyl Cellulose as a Powerful Chiral Stationary Phase for Enantioselective Chromatography.
Photochemically Immobilized 4-Methylbenzoyl Cellulose as a Powerful Chiral Stationary Phase for Enantioselective Chromatography.
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DOI：
10.3390/molecules21121740
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发表时间：
2016-12-17
期刊：
影响因子：
--
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Francotte E;Huynh D;Zhang T
发展了一种将对甲基苯甲酰纤维素(PMBC)固定在硅胶上的方法，并将其应用于手性固定相的制备。该多糖衍生物包覆在硅胶载体上后，用紫外光照射即可实现固定化。考察了辐照时间、溶剂等参数对固定化效果的影响。通过将一系列外消旋化合物注入填充柱并测定它们的手性识别能力来评价所制备的固定化相的性能。与传统的包被相相比，固定化CSP可以不受有机溶剂类型的限制，在不同的色谱条件下作为流动相使用。这种扩展的适用性允许提高选择性和拆分不能或仅在与非固定化PMBC固定相相容的流动相中难于溶解的手性化合物。
A process to immobilize para-methylbenzoyl cellulose (PMBC) on silica gel has been developed and applied to prepare chiral stationary phases (CSPs) for enantioselective chromatography. The immobilization was achieved by simple irradiation of the polysaccharide derivative with ultraviolet light after coating on a silica gel support. The influence of parameters such as irradiation time and solvent on immobilization effectiveness were investigated. The performance of the prepared immobilized phases were evaluated by injection of a series of racemic compounds onto the packed columns and determination of their chiral recognition ability. By contrast to the classical coated phase, the immobilized CSP can be used under various chromatographic conditions without limitation of organic solvent types as the mobile phase. This extended applicability permits to improve selectivity and to resolve chiral compounds which are not or only poorly soluble in the mobile phases which are compatible with the non-immobilized PMBC stationary phase.
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DOI：
10.1016/s0731-7085(01)00568-4
发表时间：
2002-01-15
影响因子：
3.4
作者：
Francotte, E;Huynh, D
通讯作者：
Huynh, D
DOI：
10.1016/0021-9673(92)85147-l
发表时间：
1992-03-20
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
--
作者：
FRANCOTTE, E;WOLF, RM
通讯作者：
WOLF, RM
影响因子：
62.1
作者：
Klan, Petr;Solomek, Tomas;Bochet, Christian G.;Blanc, Aurelien;Givens, Richard;Rubina, Marina;Popik, Vladimir;Kostikov, Alexey;Wirz, Jakob
通讯作者：
Wirz, Jakob
影响因子：
2
作者：
FRANCOTTE, E;WOLF, RM
通讯作者：
WOLF, RM
影响因子：
3.1
作者：
Wetli, Herbert A.;Francotte, Eric
通讯作者：
Francotte, Eric