Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow.
Human placental mesenchymal stem cells improve stroke outcomes via extracellular vesicles-mediated preservation of cerebral blood flow.
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人胎盘间充质干细胞通过细胞外囊泡介导的脑血流保护改善卒中预后。
DOI：
10.1016/j.ebiom.2020.103161
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发表时间：
2021-01
期刊：
影响因子：
11.1
通讯作者：
Alexander JS
中科院分区：
文献类型：
--
作者：
Barzegar M;Wang Y;Eshaq RS;Yun JW;Boyer CJ;Cananzi SG;White LA;Chernyshev O;Kelley RE;Minagar A;Stokes KY;Lu XH;Alexander JS
Besides long-term trans-differentiation into neural cells, benefits of stem cell therapy (SCT) in ischemic stroke may include secretion of protective factors, which partly reflects extracellular vesicle (EVs) released by stem cell. However, the mechanism(s) by which stem cells/EVs limit stroke injury have yet to be fully defined. We evaluated the protection effect of human placenta mesenchymal stem cells (hPMSC) as a potential form of SCT in experimental ischemic stroke ‘transient middle cerebral artery occusion (MCAO)/reperfusion’ mice model. We found for the first time that intraperitoneal administration of hPMSCs or intravenous hPMSC-derived EVs, given at the time of reperfusion, significantly protected the ipsilateral hemisphere from ischemic injury. This protection was associated with significant restoration of normal blood flow to the post-MCAO brain. More importantly, EVs derived from hPMSC promote paracrine-based protection of SCT in the MCAO model in a cholesterol/lipid-dependent manner. Together, our results demonstrated beneficial effects of hPMSC/EVs in experimental stroke models which could permit the rapid “translation” of these cells into clinical trials in the near-term.
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DOI：
10.2147/dddt.s56071
发表时间：
2015
期刊：
Drug design, development and therapy
影响因子：
--
作者：
Fluri F;Schuhmann MK;Kleinschnitz C
通讯作者：
Kleinschnitz C
影响因子：
5.3
作者：
Broughton BR;Lim R;Arumugam TV;Drummond GR;Wallace EM;Sobey CG
通讯作者：
Sobey CG
影响因子：
8.3
作者：
Chen B;Friedman B;Cheng Q;Tsai P;Schim E;Kleinfeld D;Lyden PD
通讯作者：
Lyden PD
影响因子：
5.9
作者：
Doeppner TR;Bähr M;Giebel B;Hermann DM
通讯作者：
Hermann DM
影响因子：
8.3
作者：
GARCIA, JH;WAGNER, S;HU, XJ
通讯作者：
HU, XJ